Platelet Aggregation Unchanged by Lipoprotein-Associated Phospholipase A.sub.2 Inhibition: Results from an In Vitro Study and Two Randomized Phase I Trials

We explored the theorized upregulation of platelet-activating factor (PAF)- mediated biologic responses following lipoprotein-associated phospholipase A.sub.2 (Lp-PLA.sub.2) inhibition using human platelet aggregation studies in an in vitro experiment and in 2 clinical trials. Full platelet aggregat...

Full description

Bibliographic Details

Published in:	PloS one Vol. 9; no. 1; p. e83094
Main Authors:	Shaddinger, Bonnie C, Xu, Yanmei, Roger, James H, Macphee, Colin H, Handel, Malcolm, Baidoo, Charlotte A, Magee, Mindy, Lepore, John J, Sprecher, Dennis L
Format:	Journal Article
Language:	English
Published:	Public Library of Science 27-01-2014
Subjects:	Adults Clinical trials Collagen Phospholipases
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!