Pyrrosia lingua Reduces Nociception in Mouse

• Published in: Natural product sciences Vol. 20; no. 4; pp. 285 - 289
• Main Authors: Hyun Ju Lim, Jin Kwon, Hoon Jeon
• Format: Journal Article
• Language: English
• Published: 한국생약학회 2014
• Subjects: 약학; anti-nociception; pain; Pyrrosia lingua
• ISSN: 1226-3907; 2288-9027

Pyrrosia lingua has been widely used as a traditional medicine for the treatment of lots of diseases including pain management. However pharmacological and phytochemical studies on its anti-nociceptive properties are extremely limited. In this work, we investigated the effects of methanol extract of Pyrrosia lingua (MPL, 250 and 500 mg/kg) on the both of central and peripheral nociceptive pain. The results from tail-immersion test and hotplate test revealed that MPL has potent anti-nociceptive effects on thermal nociception. In addition, MPL efficiently reduced the acetic acid-induced chemical nociception compared to indomethacin. We also carried out formalin test and MPL reduced formalin-induced pain response on both phases, suggesting MPL has anti-nociceptive activities on the central and peripheral pain. In combination test using naloxone, anti-nocicpetive activity of MPL was reduced, indicating that MPL acts as a partial opioid receptor agonist. These results suggest that MPL may be possibly used as a valuable natural product-derived painkiller. KCI Citation Count: 2