Drug release rates from four sizes of a new transdermal nitroglycerin adhesive patch

This study was conducted to determine the amount of nitroglycerin released from transdermal nitroglycerin patches of four different sizes: 3.3 cm2, 6.7 cm2, 13.3 cm2, and 20 cm2. Thirty healthy men received a single 24-hour application of each patch size according to a randomized, open-label, four-p...

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Bibliographic Details
Published in:	Clinical therapeutics Vol. 11; no. 3; p. 409
Main Authors:	Riedel, D J, Wick, K A, Hawkinson, R W, Kolars, C A, Crowley, J K, Harrison, L I, de Dennis, S R
Format:	Journal Article
Language:	English
Published:	United States 01-05-1989
Subjects:	Administration, Cutaneous Adolescent Adult Humans Male Nitroglycerin - administration & dosage Nitroglycerin - adverse effects Skin - drug effects
Online Access:	Get more information
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Summary:	This study was conducted to determine the amount of nitroglycerin released from transdermal nitroglycerin patches of four different sizes: 3.3 cm2, 6.7 cm2, 13.3 cm2, and 20 cm2. Thirty healthy men received a single 24-hour application of each patch size according to a randomized, open-label, four-period crossover design. A 24-hour interval separated each treatment period. The total amount of nitroglycerin released by the four patches was proportional to size. All four patch sizes released nitroglycerin at a comparable rate. The mean overall 24-hour release rate of 0.76 mg/cm2 was similar to the release rate of 0.75 mg/cm2/24 hr observed in a previous study. Adverse experiences common to nitroglycerin administration were reported for all patch sizes, with headache, light-headedness, and nausea reported most frequently.
ISSN:	0149-2918