PTPRG is an ischemia risk locus essential for HCO.sub.3.sup.---dependent regulation of endothelial function and tissue perfusion

Acid-base conditions modify artery tone and tissue perfusion but the involved vascular-sensing mechanisms and disease consequences remain unclear. We experimentally investigated transgenic mice and performed genetic studies in a UK-based human cohort. We show that endothelial cells express the putat...

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Bibliographic Details

Published in:	eLife Vol. 9
Main Authors:	Hansen, Kristoffer B, Staehr, Christian, Rohde, Palle D, Homilius, Casper, Kim, Sukhan, Nyegaard, Mette, Matchkov, Vladimir V, Boedtkjer, Ebbe
Format:	Journal Article
Language:	English
Published:	eLife Science Publications, Ltd 21-09-2020
Subjects:	Carbonates Disease susceptibility Endothelium Genetic engineering Ischemia Phosphatases Physiological aspects Protein binding Proteins Sensors Tyrosine
Online Access:	Get full text
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