Morphological and biochemical assessment of the liver response to excess dietary copper in Fischer 344 rats

The aim of this study was to determine the amount of excess dietary copper (Cu) necessary to experimentally induce liver lesions characteristic of Cu-associated disease in Fischer 344 rats. Male weanling Fischer 344 rats of uniform age were divided into 6 groups (n = 5) and fed a rodent diet contain...

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Bibliographic Details
Published in:	Canadian journal of veterinary research Vol. 65; no. 2; pp. 97 - 103
Main Authors:	Aburto, E.M, Cribb, A.E, Fuentealba, I.C, Ikede, B.O, Kibenge, F.S.B, Markham, F
Format:	Journal Article
Language:	English
Published:	Canada 01-04-2001
Subjects:	Animals body weight Body Weight - drug effects copper Copper - administration & dosage Copper - analysis Copper - toxicity dose response Dose-Response Relationship, Drug hepatitis histochemistry Histocytochemistry histopathology lesions lipid peroxidation Lipid Peroxidation - drug effects liver Liver - chemistry Liver - drug effects Liver - pathology Male malondialdehyde Malondialdehyde - analysis mineral excess poisoning Rats Rats, Inbred F344 species differences Spectrophotometry, Atomic - veterinary Thiobarbiturates - metabolism Time Factors
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