Viral contamination of fetal bovine serum used for tissue culture: risks and concerns

Four viral contaminants have been routinely detected in unprocessed and commercial lots of fetal bovine serum: bacteriophage, infectious bovine rhinotracheitis, parainfluenza-3 and bovine viral diarrhea virus (BVDV). Of those, BVDV is consistently present in a majority of commercial lots of fetal bo...

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Bibliographic Details
Published in:	Developments in biological standardization Vol. 75; p. 173
Main Authors:	Erickson, G A, Bolin, S R, Landgraf, J G
Format:	Journal Article
Language:	English
Published:	Switzerland 1991
Subjects:	Animals Biological Products - isolation & purification Cattle Diarrhea Viruses, Bovine Viral - isolation & purification Diarrhea Viruses, Bovine Viral - pathogenicity Drug Contamination Fetal Blood - microbiology Humans Infant, Newborn Microcephaly - etiology Viruses - isolation & purification
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Summary:	Four viral contaminants have been routinely detected in unprocessed and commercial lots of fetal bovine serum: bacteriophage, infectious bovine rhinotracheitis, parainfluenza-3 and bovine viral diarrhea virus (BVDV). Of those, BVDV is consistently present in a majority of commercial lots of fetal bovine serum. Methods for BVDV detection and removal are reviewed. The tentative role of an unclassified pestivirus in microcephaly of infants has been reported. Its significance remains uncertain.
ISSN:	0301-5149