Effect of recombinant DNA-derived bovine and human interferons on replication of bovine herpesvirus-1, parainfluenza-3, and respiratory syncytial viruses

• Published in: American journal of veterinary research Vol. 47; no. 4; p. 751
• Main Authors: Fulton, R W, Burge, L J, McCraken, J S
• Format: Journal Article
• Language: English
• Published: United States 01-04-1986
• Subjects: Animals; Cattle; Cell Line; DNA Replication - drug effects; DNA, Recombinant - metabolism; Herpesviridae - drug effects; Herpesviridae - genetics; Humans; Interferon Type I - genetics; Interferon Type I - pharmacology; Kidney; Parainfluenza Virus 3, Human - drug effects; Parainfluenza Virus 3, Human - genetics; Recombinant Proteins - pharmacology; Respiratory Syncytial Viruses - drug effects; Respiratory Syncytial Viruses - genetics; Respirovirus - genetics; Species Specificity; Virus Replication - drug effects
• ISSN: 0002-9645

Antiviral effects of recombinant DNA-derived bovine (Bo) and human (Hu) interferons (IFN) on the replication of bovine herpesvirus-1, parainfluenza-3, and respiratory syncytial viruses were studied. Bovine monolayer cultures were treated with recombinant DNA-produced Bo IFN-alpha 1, Bo IFN-beta 2, Hu IFN-alpha A, or Hu IFN-alpha A/D and then challenge exposed with bovine herpesvirus-1, bovine parainfluenza-3 virus, bovine respiratory syncytial virus, or vesicular stomatitis virus. Treatment with each IFN reduced the viral yield for each of these viruses, compared with that of control cultures.