Production of rosmarinic acid by Lavandula vera MM cell suspension in bioreactor: effect of dissolved oxygen concentration and agitation

The relationship between dissolved oxygen (DO) concentration, agitation rate and growth of Lavandula vera MM and rosmarinic acid biosynthesis was investigated in 3 l laboratory bioreactor. Lavandula vera MM cell suspension accumulated the highest amounts of biomass (34.8 g/l) and rosmarinic acid (18...

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Bibliographic Details
Published in:	World journal of microbiology & biotechnology Vol. 21; no. 4; pp. 389 - 392
Main Authors:	Pavlov, A.I, Georgiev, M.I, Ilieva, M.P
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer 01-06-2005
Subjects:	agitation Biological and medical sciences bioreactors biosynthesis Biotechnology cell suspension culture cultured cells dissolved oxygen Fundamental and applied biological sciences. Psychology Lavandula angustifolia Lavandula vera rosmarinic acid Agitation Lavandula angustifolia Lavandula vera MM Suspension rosmarinic acid Concentration Bioreactor Acids Labiatae Dicotyledones Angiospermae Production Spermatophyta Dissolved oxygen
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Summary:	The relationship between dissolved oxygen (DO) concentration, agitation rate and growth of Lavandula vera MM and rosmarinic acid biosynthesis was investigated in 3 l laboratory bioreactor. Lavandula vera MM cell suspension accumulated the highest amounts of biomass (34.8 g/l) and rosmarinic acid (1870.6 mg/l) on day 12 of cultivation at 50% dissolved oxygen and agitation speed 100 rpm and at 30% dissolved oxygen and agitation speed 300 rpm, respectively.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0959-3993 1573-0972
DOI:	10.1007/s11274-004-3982-6