Serum concentrations of trimethoprim and sulfadiazine following oral paste administration to the horse

Two fasted and 2 fed horses were dosed orally with a combined trimethoprim and sulfadiazine paste formulation at a dose of 35 mg (1:5 combined active ingredients)/kg. Serum concentrations of each drug were determined periodically for 3 consecutive days for the 4 horses. The extent and rate of absorp...

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Bibliographic Details
Published in:	American journal of veterinary research Vol. 42; no. 11; p. 2002
Main Authors:	Sigel, C W, Byars, T D, Divers, T J, Murch, O, DeAngelis, D
Format:	Journal Article
Language:	English
Published:	United States 01-01-1981
Subjects:	Animals Fasting Horses - blood Sulfadiazine - administration & dosage Sulfadiazine - blood Trimethoprim - administration & dosage Trimethoprim - blood
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Summary:	Two fasted and 2 fed horses were dosed orally with a combined trimethoprim and sulfadiazine paste formulation at a dose of 35 mg (1:5 combined active ingredients)/kg. Serum concentrations of each drug were determined periodically for 3 consecutive days for the 4 horses. The extent and rate of absorption for trimethoprim were variable, but peak serum concentrations occurred generally within 3 hours; sulfadiazine absorption was slower, reaching peak concentrations by 6 hours. Fasting did not have a consistent effect on the serum concentration profiles for either drug. Both drugs achieved serum concentrations that equaled or exceeded the minimum inhibitory concentrations necessary to inhibit the growth of certain pathogens common to the horse. Thus, the paste formulation provides an effective means of dose administration of horses.
ISSN:	0002-9645