Immune-mediated polysynovitis in four foals

The deposition of immune complexes in the synovial membrane resulted in polysynovitis in 4 foals. All 4 foals had an infection at a site other than the joints. The polysynovitis was characterized by marked effusions of affected joints and joint stiffness. Bacterial and mycoplasmal cultures of the jo...

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Bibliographic Details
Published in:	Journal of the American Veterinary Medical Association Vol. 192; no. 11; p. 1581
Main Authors:	Madison, J B, Scarratt, W K
Format:	Journal Article
Language:	English
Published:	United States 01-06-1988
Subjects:	Actinomycetales Infections - complications Actinomycetales Infections - veterinary Animals Bacterial Infections - complications Bacterial Infections - veterinary Escherichia coli Infections - complications Escherichia coli Infections - veterinary Female Horse Diseases - drug therapy Horse Diseases - etiology Horse Diseases - immunology Horses Immune Complex Diseases - drug therapy Immune Complex Diseases - immunology Immune Complex Diseases - veterinary Male Prednisolone - therapeutic use Respiratory Tract Infections - complications Respiratory Tract Infections - veterinary Rhodococcus Synovitis - drug therapy Synovitis - etiology Synovitis - immunology Synovitis - veterinary
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Summary:	The deposition of immune complexes in the synovial membrane resulted in polysynovitis in 4 foals. All 4 foals had an infection at a site other than the joints. The polysynovitis was characterized by marked effusions of affected joints and joint stiffness. Bacterial and mycoplasmal cultures of the joints did not yield growth. Staining of synovial membrane biopsy specimens with fluorescein-labeled anti-equine IgG revealed immune complexes in the synovial membrane. Immune-mediated polysynovitis might develop in foals with bacterial infections. We propose that deposition of immunoglobulin in the synovial membrane of the affected foals was caused by an increase in circulating immune complexes formed as a result of the primary disease processes.
ISSN:	0003-1488