Effects of troglitazone and metformin on glucose and lipid metabolism: Alterations of two distinct molecular pathways

Troglitazone and metformin are antidiabetic agents that belong to the thiazolidinedione and biguanide classes of drugs, respectively. To evaluate how these drugs influence fuel utilization, we compared their effects on several pathways regulating carbohydrate and lipid metabolism in vitro. Both drug...

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Bibliographic Details
Published in:	Biochemical pharmacology Vol. 54; no. 7; pp. 801 - 808
Main Authors:	Lenhard, James M, Kliewer, Steven A, Paulik, Mark A, Plunket, Kelli D, Lehmann, Jurgen M, Weiel, James E
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-10-1997 Elsevier Science
Subjects:	Animals Biological and medical sciences Biological Transport - drug effects Chromans - pharmacology diabetes General and cellular metabolism. Vitamins Glucose - metabolism Hypoglycemic Agents - pharmacology insulin Lactic Acid - metabolism Lipid Metabolism Medical sciences metabolism metformin Metformin - pharmacology Mice Mice, Inbred C3H Mitochondria - drug effects Palmitoyl Coenzyme A - metabolism Pharmacology. Drug treatments PPAR-γ Receptors, Cytoplasmic and Nuclear - drug effects Thiazoles - pharmacology Thiazolidinediones Transcription Factors - drug effects Troglitazone metformin troglitazone metabolism insulin diabetes PPAR-γ Endocrinopathy Nuclear receptor Diabetes mellitus Biological transport Lipids Activation Glucose Metabolism In vitro Insulin Lipolysis Peroxisome proliferator Hypoglycemic agent Mitochondria Biguanides Established cell line Oxidation Metformin Lipogenesis Mechanism of action Troglitazone
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