Cytochrome P450 and Parkinson's disease. Poor parahydroxylation of phenytoin

Phenytoin-parahydroxylation capacity was determined in 24 patients with Parkinson's disease (PD) and 17 controls. Different function of the phenytoin-metabolizing cytochrome P450 subsystem was found in 6 patients, but in none of the controls. These results add to previous studies suggesting a r...

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Bibliographic Details
Published in:	Journal of the neurological sciences Vol. 96; no. 2-3; p. 153
Main Authors:	Ferrari, M D, Peeters, E A, Haan, J, Roos, R A, Vermey, P, de Wolff, F A, Buruma, O J
Format:	Journal Article
Language:	English
Published:	Netherlands 01-05-1990
Subjects:	Aged Cytochrome P-450 Enzyme System - metabolism Female Humans Male Middle Aged Parkinson Disease, Secondary - metabolism Phenytoin - metabolism
Online Access:	Get more information
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Summary:	Phenytoin-parahydroxylation capacity was determined in 24 patients with Parkinson's disease (PD) and 17 controls. Different function of the phenytoin-metabolizing cytochrome P450 subsystem was found in 6 patients, but in none of the controls. These results add to previous studies suggesting a relation between the pathogenesis of PD and the function of cytochrome P450 subsystems.
ISSN:	0022-510X
DOI:	10.1016/0022-510X(90)90128-A