Synthesis, spectroscopy and antiproliferative activity of cis- and trans-platinum(II) complexes with diethyl (pyridin-4-ylmethyl)phosphate. X-ray crystal structure of trans-Pt(II) complex

• Published in: Journal of inorganic biochemistry Vol. 99; no. 10; pp. 2024 - 2031
• Main Authors: Kalinowska, Urszula, Matławska, Ksenia, Chęcińska, Lilianna, Domagała, Małgorzata, Kontek, Renata, Osiecka, Regina, Ochocki, Justyn
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-10-2005
• Subjects: Adenocarcinoma - pathology; Cell Proliferation - drug effects; cis-and trans-complexes; Colorectal Neoplasms - pathology; Cytotoxicity; Humans; Magnetic Resonance Spectroscopy; Organophosphates - chemistry; Platinum Compounds - chemical synthesis; Platinum Compounds - chemistry; Platinum Compounds - pharmacology; Platinum(II) complexes; Pyridine derivatives; Pyridines; Tumor Cells, Cultured; X-Ray Diffraction; Cytotoxicity; Platinum(II) complexes; cis-and trans-complexes; Pyridine derivatives
• ISSN: 0162-0134; 1873-3344
• DOI: 10.1016/j.jinorgbio.2005.06.030

Preparations of
cis- and
trans-platinum(II) complexes of diethyl (pyridin-4-ylmethyl)phosphate (4-pmOpe) have been described. These complexes were identified and characterized by far-IR,
1H NMR,
13C NMR,
31P NMR and
195Pt NMR and microanalyses. The crystal and molecular structure of
trans-platinum(II) complex i.e.,
trans-[PtCl
2(4-pmOpe)
2] was determined by the X-ray diffraction. Novel complexes were assayed for their potential antiproliferative effect against HT 29 (colorectal adenocarcinoma) and A 549 (non-small cell lung cancer) cell lines as well as normal human peripheral blood lymphocytes. The results obtained indicate that novel analogues of
cis-diamminedichloroplatinum(II) cause inhibition of cells growth which suggest that they could be chemotherapeutic drugs in the future.