Analysis of membrane-bound acceptors. A correction function for non-specific accumulation of poorly water-soluble hydrophobic or amphipathic ligands based on the ligand partition concept

Non-specific ligand accumulation into membrane material, which may contribute considerably to the experimental signal obtained in binding studies with labelled amphipathic and hydrophobic ligands, may be accounted for by linear partition of the ligands into the membrane phase. For application to bin...

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Bibliographic Details

Published in:	Biochemical pharmacology Vol. 43; no. 4; p. 701
Main Authors:	Heirwegh, K P, De Smedt, H, Vermeir, M
Format:	Journal Article
Language:	English
Published:	England 18-02-1992
Subjects:	Binding Sites Chemical Phenomena Chemistry, Physical Lipid Bilayers - chemistry Lipid Bilayers - metabolism Mathematics Membrane Proteins - chemistry Membrane Proteins - metabolism Solubility
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