Ternary inclusion complex formation and stabilization of limaprost, a prostaglandin E1 derivative, in the presence of α- and β-cyclodextrins in the solid state

[Display omitted] Limaprost/α-cyclodextrin (CD)/β-CD ternary inclusion complex was prepared by freeze-drying a solution containing all three components. Under humid conditions, limaprost was more stable in the ternary α-/β-CD inclusion complex than in the binary α- or β-CD complex. Specifically, dur...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 509; no. 1-2; pp. 338 - 347
Main Authors:	Inoue, Yasuo, Iohara, Daisuke, Sekiya, Noboru, Yamamoto, Masanobu, Ishida, Hiroyuki, Sakiyama, Yoko, Hirayama, Fumitoshi, Arima, Hidetoshi, Uekama, Kaneto
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 25-07-2016
Subjects:	alpha-Cyclodextrins - chemistry Alprostadil - analogs & derivatives Alprostadil - chemistry beta-Cyclodextrins - chemistry Chemistry, Pharmaceutical - methods Crystallization - methods Cyclodextrin Excipients - chemistry Freeze Drying - methods Limaprost Magnetic Resonance Spectroscopy - methods Pharmaceutical Solutions - chemistry Solid state Solubility Stability Ternary inclusion complex Solid state Cyclodextrin Stability Limaprost Ternary inclusion complex
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