The Production of γG-Globulin by Lymphocytes in Chronic Lymphocytic Leukemia Immunocytologic Investigation of a Case
A case of chronic lymphocytic leukemia associated with the excessive production of a monoclonal γG-globulin has been investigated by immunofluorescent technics. Gamma globulin was demonstrated within the cytoplasm of young and mature lymphocytes and these cells were interpreted as the cells of origi...
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| Published in: | Blood Vol. 27; no. 2; pp. 187 - 198 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Inc
01-02-1966
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| Abstract | A case of chronic lymphocytic leukemia associated with the excessive production of a monoclonal γG-globulin has been investigated by immunofluorescent technics. Gamma globulin was demonstrated within the cytoplasm of young and mature lymphocytes and these cells were interpreted as the cells of origin of the monoclonal protein. The finding of gamma globulin within the cytoplasm of mature small lymphocytes in the absence of any apparent morphologic relationship with the occasional plasma cells present was interpreted as indicating a population of gamma globulin forming cells distinct from plasma cells, and suggested that a small number of lymphocytes may also contribute to the formation of immunoglobulins under normal conditions. The distribution of the fluorescent lymphocytes in sharply defined small and large cells groups within a lymph node supports the concept of the clonal origin of single molecular species of gamma globulin. |
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| AbstractList | A case of chronic lymphocytic leukemia associated with the excessive production of a monoclonal γG-globulin has been investigated by immunofluorescent technics. Gamma globulin was demonstrated within the cytoplasm of young and mature lymphocytes and these cells were interpreted as the cells of origin of the monoclonal protein. The finding of gamma globulin within the cytoplasm of mature small lymphocytes in the absence of any apparent morphologic relationship with the occasional plasma cells present was interpreted as indicating a population of gamma globulin forming cells distinct from plasma cells, and suggested that a small number of lymphocytes may also contribute to the formation of immunoglobulins under normal conditions. The distribution of the fluorescent lymphocytes in sharply defined small and large cells groups within a lymph node supports the concept of the clonal origin of single molecular species of gamma globulin. |
| Author | Gamble, Charles N. Cutting, Hunter O. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/4159148$$D View this record in MEDLINE/PubMed |
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| Copyright | 1966 American Society of Hematology |
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| DOI | 10.1182/blood.V27.2.187.187 |
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| References_xml | – volume: 5 start-page: 317 year: 1956 ident: bib25 article-title: Preparation of ultra thin tissue sections for electron miiicroscopy publication-title: Lab. Invest contributor: fullname: Farquhar – volume: 103 start-page: 565 year: 1940 ident: bib30 article-title: Further investigations of hypergammaglobulinemia publication-title: I and II. Acta Med. Scand contributor: fullname: Bing – volume: 10 start-page: 1110 year: 1961 ident: bib9 article-title: Antibody—or gamma globulin—forming cells as observed by the fluorescent antibody technique publication-title: Lab. Invest. 10:1110 contributor: fullname: Vazquez – volume: 17 start-page: 471 year: 1946 ident: bib33 article-title: Aspiration biopsy of bone marrow. Staff Meet publication-title: Bull. Hosp.U. Minn contributor: fullname: Simndberg – start-page: 1 year: 1960 ident: bib23 article-title: Lymphocytes. Origin, structure and interrelationships publication-title: In (J. W. Rebuck, Ed.). 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| SubjectTerms | Aged Blood Cell Count Blood Protein Disorders Blood Protein Electrophoresis Bone Marrow Examination Fluorescent Antibody Technique gamma-Globulins - biosynthesis Humans Immunodiffusion Immunoelectrophoresis Leukemia, Lymphoid - immunology Lymphocytes Male Microscopy, Electron |
| Title | The Production of γG-Globulin by Lymphocytes in Chronic Lymphocytic Leukemia Immunocytologic Investigation of a Case |
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