The in vitro activation of cyclophosphamide in the Hydra Developmental Toxicology Assay

The proteratogen cyclophosphamide (CP) was tested in the Hydra Assay in the presence and absence of an in vitro metabolic activation package (MAP) consisting of rat hepatic microsomes (0.06 nmol P450/ml), 500 microM NADPH, and 25 microM MgCl. This metabolic system was developed through a series of i...

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Bibliographic Details

Published in:	Fundamental and applied toxicology Vol. 15; no. 3; p. 488
Main Authors:	Newman, L M, Johnson, E M, Giacobbe, R L, Fu, L J
Format:	Journal Article
Language:	English
Published:	United States 01-10-1990
Subjects:	Animals Biological Assay Biotransformation Cyclophosphamide - pharmacokinetics Cyclophosphamide - toxicity Hydra - drug effects Hydra - growth & development In Vitro Techniques Microsomes, Liver - metabolism Mixed Function Oxygenases - metabolism Rats Teratogens - pharmacokinetics
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