Predictive factors for clinical pregnancies of poor responders diagnosed according to the Bologna criteria in ovarian stimulation in vitro fertilization (IVF)
To explore the predictive factors for clinical pregnancies of poor responders diagnosed according to the Bologna criteria in ovarian stimulation in vitro fertilization (IVF). The present study included 392 poor responders diagnosed according to the Bologna criteria (392 first poor response cycles an...
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| Published in: | Journal of reproduction and contraception Vol. 26; no. 3; pp. 141 - 145 |
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| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
01-09-2015
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| Abstract | To explore the predictive factors for clinical pregnancies of poor responders diagnosed according to the Bologna criteria in ovarian stimulation in vitro fertilization (IVF).
The present study included 392 poor responders diagnosed according to the Bologna criteria (392 first poor response cycles and 247 subsequent conventional stimulation cycles) in our IVF center. Binary Logistic regression analysis was used to study the association between possible predictive factors and clinical pregnancy of poor responders in ovarian stimulation IVF.
The significant predictive factors for clinical pregnancies of poor responders in ovarian stimulation IVF were female age, number of embryos transferred and ovarian stimulation protocol. Female age had the best predictive value for clinical pregnancy of poor ovarian responders.
Poor responders should be encouraged to attempt further ovarian stimulation IVF treatment as soon as possible because the pregnancy rate decreases with advancing female age. Growth hormone supplementation, intracytoplasmic sperm injection (ICSI) procedure or assisted hatching seem not be able to prominently improve the pregnancy outcomes of poor responders diagnosed according to the Bologna criteria in ovarian stimulation IVF. |
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| AbstractList | To explore the predictive factors for clinical pregnancies of poor responders diagnosed according to the Bologna criteria in ovarian stimulation in vitro fertilization (IVF).
The present study included 392 poor responders diagnosed according to the Bologna criteria (392 first poor response cycles and 247 subsequent conventional stimulation cycles) in our IVF center. Binary Logistic regression analysis was used to study the association between possible predictive factors and clinical pregnancy of poor responders in ovarian stimulation IVF.
The significant predictive factors for clinical pregnancies of poor responders in ovarian stimulation IVF were female age, number of embryos transferred and ovarian stimulation protocol. Female age had the best predictive value for clinical pregnancy of poor ovarian responders.
Poor responders should be encouraged to attempt further ovarian stimulation IVF treatment as soon as possible because the pregnancy rate decreases with advancing female age. Growth hormone supplementation, intracytoplasmic sperm injection (ICSI) procedure or assisted hatching seem not be able to prominently improve the pregnancy outcomes of poor responders diagnosed according to the Bologna criteria in ovarian stimulation IVF. |
| Author | KE, Hui YAN, Li-zheng |
| Author_xml | – sequence: 1 givenname: Hui surname: KE fullname: KE, Hui email: kehui_KH@163.com – sequence: 2 givenname: Li-zheng surname: YAN fullname: YAN, Li-zheng |
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| ContentType | Journal Article |
| Copyright | 2015 The Editorial Board of Journal of Reproduction and Contraception |
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| DOI | 10.7669/j.issn.1001-7844.2015.03.0141 |
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| Keywords | poor responders Bologna criteria in vitro fertilization (IVF) clinical pregnancy |
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| References_xml | – volume: 31 start-page: 253 year: 2015 end-page: 257 ident: bib9 article-title: Poor responders in IVF: an update in therapy publication-title: Gynecol Endocrinol contributor: fullname: Ralli – volume: 92 start-page: 481 year: 2009 end-page: 485 ident: bib20 article-title: Comparison of microdose flare-up and antagonist multiple-dose protocols for poor-responder patients: a randomized study publication-title: Fertil Steril contributor: fullname: Gurgan – volume: 92 start-page: 1758 year: 2009 end-page: 1760 ident: bib15 article-title: Comparison of GnRH antagonist protocol with or without oral contraceptive pill pretreatment and GnRH agonist low-dose long protocol in low responders undergoing IVF/intracytoplasmic sperm injection publication-title: Fertil Steril contributor: fullname: Cheon – volume: 95 start-page: 2531 year: 2011 end-page: 2533 ident: bib19 article-title: A randomized trial of microdose leuprolide acetate protocol versus luteal phase ganirelix protocol in predicted poor responders publication-title: Fertil Steril contributor: fullname: Schmidt – volume: 26 start-page: 1616 year: 2011 end-page: 1624 ident: bib6 article-title: ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for publication-title: Hum Reprod contributor: fullname: Fauser – volume: 6 start-page: 439 year: 2003 end-page: 443 ident: bib2 article-title: Conception rates following assisted reproduction in poor responder patients: a retrospective study in 300 consecutive cycles publication-title: Reprod Biomed Online contributor: fullname: Turan – volume: 287 start-page: 1017 year: 2013 end-page: 1021 ident: bib25 article-title: Adjuvant growth hormone therapy in antagonist protocol in poor responders undergoing assisted reproductive technology publication-title: Arch Gynecol Obstet contributor: fullname: Mohammadian – volume: 25 start-page: 123 year: 2008 end-page: 127 ident: bib26 article-title: Growth hormone co-treatment within a GnRH agonist long protocol in patients with poor ovarian response: a prospective, randomized, clinical trial publication-title: J Assist Reprod Genet contributor: fullname: Kaba – volume: 13 start-page: 2126 year: 1998 end-page: 2129 ident: bib28 article-title: Intracytoplasmic sperm injection as a routine indication in low responder patients publication-title: Hum Reprod contributor: fullname: Simon – volume: 25 start-page: 17 year: 2008 end-page: 22 ident: bib11 article-title: The clinical analysis of poor ovarian response in in-vitro-fertilization embryotransfer among Chinese couples publication-title: J Assist Reprod Genet contributor: fullname: Li – volume: 25 start-page: 683 year: 2010 end-page: 689 ident: bib8 article-title: Flexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective randomised controlled trial (RCT) publication-title: Hum Reprod contributor: fullname: Zorzovilis – volume: 91 start-page: 2437 year: 2009 end-page: 2444 ident: bib21 article-title: Microdose gonadotropin-releasing hormone agonist flare-up protocol versus multiple dose gonadotropin-releasing hormone antagonist protocol in poor responders undergoing intracytoplasmic sperm injection-embryo transfer cycle publication-title: Fertil Steril contributor: fullname: Atabekoglu – volume: 52 start-page: 313 year: 1996 end-page: 343 ident: bib1 article-title: fertilisation. 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| SubjectTerms | Bologna criteria clinical pregnancy in vitro fertilization (IVF) poor responders |
| Title | Predictive factors for clinical pregnancies of poor responders diagnosed according to the Bologna criteria in ovarian stimulation in vitro fertilization (IVF) |
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