Sufentanil sublingual tablet 30mcg for moderate-to-severe acute pain in the ED
Pharmacological properties of the sufentanil sublingual tablet 30mcg (SST 30mcg) could offer potential analgesic advantages in settings requiring noninvasive, acute pain management. The feasibility of using SST 30mcg for moderate-to-severe pain management in the emergency department (ED) was evaluat...
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| Published in: | The American journal of emergency medicine Vol. 36; no. 6; pp. 954 - 961 |
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| Main Authors: | , , , , |
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01-06-2018
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| Abstract | Pharmacological properties of the sufentanil sublingual tablet 30mcg (SST 30mcg) could offer potential analgesic advantages in settings requiring noninvasive, acute pain management. The feasibility of using SST 30mcg for moderate-to-severe pain management in the emergency department (ED) was evaluated.
This open-label, multicenter feasibility study included patients aged ≥18years who presented to the ED with moderate-to-severe pain (≥4 on the numeric rating scale of pain intensity (NRS); opioid-tolerant patients were excluded. Patients received a single SST 30-mcg dose (single-dose cohort) or, upon request, ≤3 additional doses ≥60min apart (multiple-dose cohort) and were evaluated over 1 or 2h. Effectiveness was assessed by patient-reported pain scores (11-point NRS; 5-point pain relief scale). Safety and tolerability were also assessed.
Overall, 76 patients enrolled into the single-dose (n=40) and multiple-dose (n=36) cohorts. In the first hour (combined cohorts), mean pain intensity was significantly lower 15-min post-dosing (P<0.001; clinically meaningful within 30-minutes post-dosing) and continued to decrease during the first hour (P<0.001 for each 15-minute interval). Mean pain intensity (multiple-dose cohort) decreased from 7.6 at baseline to 4.5 at 1h and to 4.6 at 2h (P<0.001 for both); mean pain relief increased from baseline to 1.9 at 1h (P<0.001) and to 2.0 at 2h (P<0.001). Most (79%) patients had no adverse events (AEs), and there were no severe AEs.
SST 30mcg was feasible for managing moderate-to-severe acute pain in an ED setting. |
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| AbstractList | Pharmacological properties of the sufentanil sublingual tablet 30mcg (SST 30mcg) could offer potential analgesic advantages in settings requiring noninvasive, acute pain management. The feasibility of using SST 30mcg for moderate-to-severe pain management in the emergency department (ED) was evaluated.
This open-label, multicenter feasibility study included patients aged ≥18years who presented to the ED with moderate-to-severe pain (≥4 on the numeric rating scale of pain intensity (NRS); opioid-tolerant patients were excluded. Patients received a single SST 30-mcg dose (single-dose cohort) or, upon request, ≤3 additional doses ≥60min apart (multiple-dose cohort) and were evaluated over 1 or 2h. Effectiveness was assessed by patient-reported pain scores (11-point NRS; 5-point pain relief scale). Safety and tolerability were also assessed.
Overall, 76 patients enrolled into the single-dose (n=40) and multiple-dose (n=36) cohorts. In the first hour (combined cohorts), mean pain intensity was significantly lower 15-min post-dosing (P<0.001; clinically meaningful within 30-minutes post-dosing) and continued to decrease during the first hour (P<0.001 for each 15-minute interval). Mean pain intensity (multiple-dose cohort) decreased from 7.6 at baseline to 4.5 at 1h and to 4.6 at 2h (P<0.001 for both); mean pain relief increased from baseline to 1.9 at 1h (P<0.001) and to 2.0 at 2h (P<0.001). Most (79%) patients had no adverse events (AEs), and there were no severe AEs.
SST 30mcg was feasible for managing moderate-to-severe acute pain in an ED setting. BACKGROUNDPharmacological properties of the sufentanil sublingual tablet 30mcg (SST 30mcg) could offer potential analgesic advantages in settings requiring noninvasive, acute pain management. The feasibility of using SST 30mcg for moderate-to-severe pain management in the emergency department (ED) was evaluated.METHODSThis open-label, multicenter feasibility study included patients aged ≥18years who presented to the ED with moderate-to-severe pain (≥4 on the numeric rating scale of pain intensity (NRS); opioid-tolerant patients were excluded. Patients received a single SST 30-mcg dose (single-dose cohort) or, upon request, ≤3 additional doses ≥60min apart (multiple-dose cohort) and were evaluated over 1 or 2h. Effectiveness was assessed by patient-reported pain scores (11-point NRS; 5-point pain relief scale). Safety and tolerability were also assessed.RESULTSOverall, 76 patients enrolled into the single-dose (n=40) and multiple-dose (n=36) cohorts. In the first hour (combined cohorts), mean pain intensity was significantly lower 15-min post-dosing (P<0.001; clinically meaningful within 30-minutes post-dosing) and continued to decrease during the first hour (P<0.001 for each 15-minute interval). Mean pain intensity (multiple-dose cohort) decreased from 7.6 at baseline to 4.5 at 1h and to 4.6 at 2h (P<0.001 for both); mean pain relief increased from baseline to 1.9 at 1h (P<0.001) and to 2.0 at 2h (P<0.001). Most (79%) patients had no adverse events (AEs), and there were no severe AEs.CONCLUSIONSSST 30mcg was feasible for managing moderate-to-severe acute pain in an ED setting. |
| Author | Minkowitz, Harold S. Rafique, Zubaid Palmer, Pamela P. Miner, James R. DiDonato, Karen P. |
| Author_xml | – sequence: 1 givenname: James R. surname: Miner fullname: Miner, James R. email: James.Miner@hcmed.org organization: Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN, United States – sequence: 2 givenname: Zubaid surname: Rafique fullname: Rafique, Zubaid email: zubaidrafique@gmail.com organization: Department of Emergency Medicine, Baylor College of Medicine, Ben Taub General Hospital, Houston, TX, United States – sequence: 3 givenname: Harold S. surname: Minkowitz fullname: Minkowitz, Harold S. email: harold@minkowitzmd.com organization: Department of Anesthesiology, Memorial Hermann-Memorial City Medical Center, Houston, TX, United States – sequence: 4 givenname: Karen P. surname: DiDonato fullname: DiDonato, Karen P. email: kdidonato@acelrx.com organization: Department of Medical and Clinical Affairs, AcelRx Pharmaceuticals, Redwood City, CA, United States – sequence: 5 givenname: Pamela P. orcidid: 0000-0002-0384-7624 surname: Palmer fullname: Palmer, Pamela P. email: ppalmer@acelrx.com organization: Department of Medical and Clinical Affairs, AcelRx Pharmaceuticals, Redwood City, CA, United States |
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| Issue | 6 |
| Keywords | Analgesics, opioid Clinical trial Administration, oral Acute pain Emergency service, hospital |
| Language | English |
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| References | Vaurio, Sands, Wang, Mullen, Leung (bb0180) 2006; 102 Hwang, Richardson, Harris, Morrison (bb0195) 2010; 58 Miner, Moore, Gray, Skinner, Biros (bb0030) 2008; 15 Birnbaum, Esses, Bijur, Holden, Gallagher (bb0305) 2007; 49 Kamper, Maher, Mackay (bb0140) 2009; 17 Witting, Moayedi, Brown, Ismail (bb0015) 2017; 53 Singla, Muse, Evashenk, Palmer (bb0080) 2014; 77 Leung, Sands, Lim, Tsai, Kinjo (bb0185) 2013; 21 Mather (bb0040) 1995; 22 Motov (bb0005) 2009; 2 Cinar, Ernst, Fosnocht (bb0205) 2012; 60 Todd, Ducharme, Choiniere (bb0010) 2007; 8 Ratka, Wittwer, Baker, Kern (bb0295) 2004; 14 Angaramo G, Jodka P, Heard SO. Management of acute pain in the intensive care unit in: Vincent J-L, Abraham E, Kochanek P, Moore FA, Fink MP, editors. Textbook of critical care, 6th ed, Philadelphia: Elsevier Saunders; 2011, p. 11–13. Willsie, Evashenk, Hamel, Hwang, Chiang, Palmer (bb0055) 2015; 37 Minkowitz, Scranton, Gruschkus, Nipper-Johnson, Menditto, Dandappanavar (bb0270) 2014; 20 Smith (bb0060) 2011; 27 Ashby, Fleming, Wood, Somogyi (bb0275) 1997; 14 Krebs, Carey, Weinberger (bb0100) 2007; 22 Dolin, Cashman (bb0290) 2005; 95 Lötsch (bb0045) 2005; 29 Daoust, Paquet, Lavigne, Piette, Chauny (bb0235) 2015; 20 Chang, Bijur, Davitt, Gallagher (bb0240) 2009; 54 Morrison, Magaziner, Gilbert (bb0215) 2003; 58 Patanwala, Keim, Erstad (bb0250) 2010; 44 Wright, Mather, Smith (bb0265) 2001; 69 Callahan, Unverzagt, Hui, Perkins, Hendrie (bb0145) 2002; 40 Kerr, Hill, Coda (bb0160) 1991; 5 Felson, Anderson, Boers (bb0135) 1993; 36 Ringold, Minkowitz, Gan (bb0075) 2015; 40 Paramanandam, Prommer, Schwenke (bb0280) 2011; 14 Hawker, Mian, Kendzerska, French (bb0110) 2011; 63 Behzadnia, Javadzadeh, Saboori (bb0245) 2012; 17 Bijur, Kenny, Gallagher (bb0300) 2005; 46 Melson, Boyer, Minkowitz (bb0065) 2014; 14 Green, Roback, Kennedy, Krauss (bb0150) 2011; 57 Collins, Edwards, Moore, Smith, McQuay (bb0125) 2001; 91 Shafer, Flood (bb0255) 2007 Smith (bb0260) 2000; 27 Boonstra, Stewart, Köke (bb0095) 2016; 7 Auret, Schug (bb0190) 2005; 22 Pines, Hollander (bb0025) 2008; 51 Scott, Cooke, Stanski (bb0050) 1991; 74 American Society of Anesthesiologists (bb0085) 2014 Bijur, Latimer, Gallagher (bb0155) 2003; 10 Lee, Ganta, Horton, Chai (bb0285) 2016; 19 Cromhout (bb0230) 2003; 15 Zacny, Lichtor, Flemming, Coalson, Thompson (bb0165) 1994; 268 Sieber, Mears, Lee, Gottschalk (bb0210) 2011; 59 Sherry, Ham (bb0035) 2010 Jove, Griffin, Minkowitz, Ben-David, Evashenk, Palmer (bb0070) 2015; 123 Miner, Martel, Meyer, Reardon, Biros (bb0090) 2005; 12 Singla, Hunsinger, Chang (bb0105) 2015; 16 Platts-Mills, Esserman, Brown, Bortsov, Sloane, McLean (bb0200) 2012; 60 Rothman, Vallow, Damaraju, Hewitt (bb0130) 2009; 25 Sokoloff, Daoust, Paquet, Chauny (bb0020) 2014; 4 Jensen, Karoly, Braver (bb0120) 1986; 27 Vella-Brincat, Macleod (bb0170) 2007; 21 Gaudreau, Gagnon, Roy, Harel, Tremblay (bb0175) 2007; 109 Downie, Leatham, Rhind, Wright, Branco, Anderson (bb0115) 1978; 37 Butler, Kotwal, Buckenmaier (bb0220) 2014; 14 |
| References_xml | – volume: 59 start-page: 2256 year: 2011 end-page: 2262 ident: bb0210 article-title: Postoperative opioid consumption and its relationship to cognitive function in older adults with hip fracture publication-title: J Am Geriatrics Soc contributor: fullname: Gottschalk – volume: 44 start-page: 1800 year: 2010 end-page: 1809 ident: bb0250 article-title: Intravenous opioids for severe acute pain in the emergency department publication-title: Ann Pharmacother contributor: fullname: Erstad – volume: 60 start-page: 207 year: 2012 end-page: 211 ident: bb0205 article-title: Geriatric patients may not experience increased risk of oligoanalgesia in the emergency department publication-title: Ann Emerg Med contributor: fullname: Fosnocht – volume: 14 start-page: 679 year: 2014 end-page: 688 ident: bb0065 article-title: Sufentanil sublingual tablet system vs. intravenous patient-controlled analgesia with morphine for postoperative pain control: a randomized, active-comparator trial publication-title: Pain Pract contributor: fullname: Minkowitz – year: 2010 ident: bb0035 article-title: Challenges and solutions in difficult vascular access contributor: fullname: Ham – volume: 77 start-page: S198 year: 2014 end-page: S203 ident: bb0080 article-title: Dose-finding study of sufentanil sublingual microtablets for the management of postoperative bunionectomy pain publication-title: J Trauma Acute Care Surg contributor: fullname: Palmer – volume: 95 start-page: 584 year: 2005 end-page: 591 ident: bb0290 article-title: Tolerability of acute postoperative pain management: nausea, vomiting, sedation, pruritus, and urinary retention. Evidence from published data publication-title: Br J Anaesth contributor: fullname: Cashman – volume: 5 start-page: 157 year: 1991 end-page: 166 ident: bb0160 article-title: Concentration-related effects of morphine on cognition and motor control in human subjects publication-title: Neuropsychopharmacology contributor: fullname: Coda – volume: 20 start-page: 23 year: 2015 end-page: 28 ident: bb0235 article-title: Impact of age, sex and route of administration on adverse events after opioid treatment in the emergency department: a retrospective study publication-title: Pain Res Manag contributor: fullname: Chauny – start-page: 209 year: 2007 end-page: 228 ident: bb0255 article-title: The pharmacology of opioids publication-title: Geriatric anesthesiology contributor: fullname: Flood – volume: 4 year: 2014 ident: bb0020 article-title: Is adequate pain relief and time to analgesia associated with emergency department length of stay? A retrospective study publication-title: BMJ Open contributor: fullname: Chauny – volume: 123 start-page: 434 year: 2015 end-page: 443 ident: bb0070 article-title: Sufentanil sublingual tablet system for the management of postoperative pain after knee or hip arthroplasty: a randomized, placebo-controlled study publication-title: Anesthesiology contributor: fullname: Palmer – year: 2014 ident: bb0085 article-title: ASA physician status classification system contributor: fullname: American Society of Anesthesiologists – volume: 37 start-page: 378 year: 1978 end-page: 381 ident: bb0115 article-title: Studies with pain rating scales publication-title: Ann Rheum Dis contributor: fullname: Anderson – volume: 15 start-page: 1234 year: 2008 end-page: 1240 ident: bb0030 article-title: Oral versus intravenous opioid dosing for the initial treatment of acute musculoskeletal pain in the emergency department publication-title: Acad Emerg Med contributor: fullname: Biros – volume: 40 start-page: 22 year: 2015 end-page: 30 ident: bb0075 article-title: Sufentanil sublingual tablet system for the management of postoperative pain following open abdominal surgery: a randomized, placebo-controlled study publication-title: Reg Anesth Pain Med contributor: fullname: Gan – volume: 102 start-page: 1267 year: 2006 end-page: 1273 ident: bb0180 article-title: Postoperative delirium: the importance of pain and pain management publication-title: Anesth Analg contributor: fullname: Leung – volume: 91 start-page: 189 year: 2001 end-page: 194 ident: bb0125 article-title: Seeking a simple measure of analgesia for mega-trials: is a single global assessment good enough? publication-title: Pain contributor: fullname: McQuay – volume: 40 start-page: 771 year: 2002 end-page: 781 ident: bb0145 article-title: Six-item screener to identify cognitive impairment among potential subjects for clinical research publication-title: Med Care contributor: fullname: Hendrie – volume: 14 start-page: 13 year: 2014 end-page: 25 ident: bb0220 article-title: A triple-option analgesia plan for tactical combat casualty care: TCCC guidelines change 13-04 publication-title: J Spec Oper Med contributor: fullname: Buckenmaier – volume: 109 start-page: 2365 year: 2007 end-page: 2373 ident: bb0175 article-title: Opioid medications and longitudinal risk of delirium in hospitalized cancer patients publication-title: Cancer contributor: fullname: Tremblay – volume: 27 start-page: 117 year: 1986 end-page: 126 ident: bb0120 article-title: The measurement of clinical pain intensity: a comparison of six methods publication-title: Pain contributor: fullname: Braver – volume: 2 start-page: 5 year: 2009 end-page: 11 ident: bb0005 article-title: Problems and barriers of pain management in the emergency department: are we ever going to get better? publication-title: J Pain Res contributor: fullname: Motov – volume: 53 start-page: 172 year: 2017 end-page: 177 ident: bb0015 article-title: Predictors and delays associated with the need for advanced techniques for intravenous access publication-title: J Emerg Med contributor: fullname: Ismail – volume: 14 start-page: 1029 year: 2011 end-page: 1033 ident: bb0280 article-title: Adverse effects in hospice patients with chronic kidney disease receiving hydromorphone publication-title: J Palliat Med contributor: fullname: Schwenke – volume: 27 start-page: 824 year: 2011 end-page: 838 ident: bb0060 article-title: The metabolism of opioid agents and the clinical impact of their active metabolites publication-title: Clin J Pain contributor: fullname: Smith – volume: 74 start-page: 34 year: 1991 end-page: 42 ident: bb0050 article-title: Electroencephalographic quantitation of opioid effect: comparative pharmacodynamics of fentanyl and sufentanil publication-title: Anesthesiology contributor: fullname: Stanski – volume: 12 start-page: 124 year: 2005 end-page: 128 ident: bb0090 article-title: Procedural sedation of critically ill patients in the emergency department publication-title: Acad Emerg Med contributor: fullname: Biros – volume: 58 start-page: 76 year: 2003 end-page: 81 ident: bb0215 article-title: Relationship between pain and opioid analgesics on the development of delirium following hip fracture publication-title: J Gerontol A Biol Sci Med Sci contributor: fullname: Gilbert – volume: 29 start-page: S90 year: 2005 end-page: S103 ident: bb0045 article-title: Pharmacokinetic-pharmacodynamic modeling of opioids publication-title: J Pain Symptom Manage contributor: fullname: Lötsch – volume: 21 start-page: 15 year: 2007 end-page: 25 ident: bb0170 article-title: Adverse effects of opioids on the central nervous systems of palliative care patients publication-title: J. Pain Palliat. Care Pharmacother. contributor: fullname: Macleod – volume: 57 start-page: 449 year: 2011 end-page: 461 ident: bb0150 article-title: Clinical practice guideline for emergency department ketamine dissociative sedation: 2011 update publication-title: Ann Emerg Med contributor: fullname: Krauss – volume: 60 start-page: 199 year: 2012 end-page: 206 ident: bb0200 article-title: Older US emergency department patients are less likely to receive pain medication than younger patients: results from a national survey publication-title: Ann Emerg Med contributor: fullname: McLean – volume: 46 start-page: 362 year: 2005 end-page: 367 ident: bb0300 article-title: Intravenous morphine at 0.1 publication-title: Ann Emerg Med contributor: fullname: Gallagher – volume: 36 start-page: 729 year: 1993 end-page: 740 ident: bb0135 article-title: The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. The committee on outcome measures in rheumatoid arthritis clinical trials publication-title: Arthritis Rheum contributor: fullname: Boers – volume: 16 start-page: 683 year: 2015 end-page: 691 ident: bb0105 article-title: Assay sensitivity of pain intensity versus pain relief in acute pain clinical trials: ACTTION systematic review and meta-analysis publication-title: J Pain contributor: fullname: Chang – volume: 22 start-page: 833 year: 1995 end-page: 836 ident: bb0040 article-title: Opioids: a pharmacologist's delight publication-title: Clin Exp Pharmacol Physiol contributor: fullname: Mather – volume: 14 start-page: 45 year: 2004 end-page: 55 ident: bb0295 article-title: Pharmacokinetics of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in healthy older men and women publication-title: Am J Pain Manag contributor: fullname: Kern – volume: 7 year: 2016 ident: bb0095 article-title: Cut-off points for mild, moderate, and severe pain on the numeric rating scale for pain in patients with chronic musculoskeletal pain: variability and influence of sex and catastrophizing publication-title: Front. Psychol. contributor: fullname: Köke – volume: 14 start-page: 157 year: 1997 end-page: 167 ident: bb0275 article-title: Plasma morphine and glucuronide (M3G and M6G) concentrations in hospice inpatients publication-title: J Pain Symptom Manage contributor: fullname: Somogyi – volume: 69 start-page: 409 year: 2001 end-page: 420 ident: bb0265 article-title: Hydromorphone-3-glucuronide: a more potent neuro-excitant than its structural analogue, morphine-3-glucuronide publication-title: Life Sci contributor: fullname: Smith – volume: 49 start-page: 445 year: 2007 end-page: 453 ident: bb0305 article-title: Randomized double-blind placebo-controlled trial of two intravenous morphine dosages (0.10 publication-title: Ann Emerg Med contributor: fullname: Gallagher – volume: 17 start-page: 329 year: 2012 ident: bb0245 article-title: Time of admission, gender and age: challenging factors in emergency renal colic-a preliminary study publication-title: Trauma Monthly contributor: fullname: Saboori – volume: 19 start-page: 1179 year: 2016 end-page: 1187 ident: bb0285 article-title: Evidence for neurotoxicity due to morphine or hydromorphone in renal impairment: a systematic review publication-title: J Palliat Med contributor: fullname: Chai – volume: 21 start-page: 946 year: 2013 end-page: 956 ident: bb0185 article-title: Does preoperative risk for delirium moderate the effects of postoperative pain and opiate use on postoperative delirium? publication-title: Am J Geriatr Psychiatry contributor: fullname: Kinjo – volume: 17 start-page: 163 year: 2009 end-page: 170 ident: bb0140 article-title: Global rating of change scales: a review of strengths and weaknesses and considerations for design publication-title: J Man Manip Ther contributor: fullname: Mackay – volume: 58 start-page: 2122 year: 2010 end-page: 2128 ident: bb0195 article-title: The quality of emergency department pain care for older adult patients publication-title: J. Am. Geriatr. Soc. contributor: fullname: Morrison – volume: 51 start-page: 1 year: 2008 end-page: 5 ident: bb0025 article-title: Emergency department crowding is associated with poor care for patients with severe pain publication-title: Ann Emerg Med contributor: fullname: Hollander – volume: 15 start-page: 155 year: 2003 end-page: 159 ident: bb0230 article-title: Ketamine: its use in the emergency department publication-title: Emerg Med contributor: fullname: Cromhout – volume: 25 start-page: 1433 year: 2009 end-page: 1443 ident: bb0130 article-title: Using the patient global assessment of the method of pain control to assess new analgesic modalities in clinical trials publication-title: Curr Med Res Opin contributor: fullname: Hewitt – volume: 20 start-page: 948 year: 2014 end-page: 958 ident: bb0270 article-title: Development and validation of a risk score to identify patients at high risk for opioid-related adverse drug events publication-title: J Manag Care Pharm contributor: fullname: Dandappanavar – volume: 22 start-page: 1453 year: 2007 end-page: 1458 ident: bb0100 article-title: Accuracy of the pain numeric rating scale as a screening test in primary care publication-title: J Gen Intern Med contributor: fullname: Weinberger – volume: 268 start-page: 1 year: 1994 end-page: 9 ident: bb0165 article-title: A dose-response analysis of the subjective, psychomotor and physiological effects of intravenous morphine in healthy volunteers publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Thompson – volume: 54 start-page: 561 year: 2009 end-page: 567 ident: bb0240 article-title: Randomized clinical trial comparing a patient-driven titration protocol of intravenous hydromorphone with traditional physician-driven management of emergency department patients with acute severe pain publication-title: Ann Emerg Med contributor: fullname: Gallagher – volume: 10 start-page: 390 year: 2003 end-page: 392 ident: bb0155 article-title: Validation of a verbally administered numerical rating scale of acute pain for use in the emergency department publication-title: Acad Emerg Med contributor: fullname: Gallagher – volume: 27 start-page: 524 year: 2000 end-page: 528 ident: bb0260 article-title: Neuroexcitatory effects of morphine and hydromorphone: evidence implicating the 3-glucuronide metabolites publication-title: Clin Exp Pharmacol Physiol contributor: fullname: Smith – volume: 22 start-page: 641 year: 2005 end-page: 654 ident: bb0190 article-title: Underutilisation of opioids in elderly patients with chronic pain publication-title: Drugs Aging contributor: fullname: Schug – volume: 37 start-page: 145 year: 2015 end-page: 155 ident: bb0055 article-title: Pharmacokinetic properties of single-and repeated-dose sufentanil sublingual tablets in healthy volunteers publication-title: Clin Ther contributor: fullname: Palmer – volume: 63 start-page: S240 year: 2011 end-page: 52 ident: bb0110 article-title: Measures of adult pain: visual analog scale for pain (VAS pain), numeric rating scale for pain (NRS pain), McGill pain questionnaire (MPQ), short-form McGill pain questionnaire (SF-MPQ), chronic pain grade scale (CPGS), short Form-36 bodily pain scale (SF-36 BPS), and measure of intermittent and constant osteoarthritis pain (ICOAP) publication-title: Arthritis Care Res. contributor: fullname: French – volume: 8 start-page: 460 year: 2007 end-page: 466 ident: bb0010 article-title: Pain in the emergency department: results of the pain and emergency medicine initiative (PEMI) multicenter study publication-title: J Pain contributor: fullname: Choiniere |
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| Snippet | Pharmacological properties of the sufentanil sublingual tablet 30mcg (SST 30mcg) could offer potential analgesic advantages in settings requiring noninvasive,... BACKGROUNDPharmacological properties of the sufentanil sublingual tablet 30mcg (SST 30mcg) could offer potential analgesic advantages in settings requiring... |
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| SubjectTerms | Acute pain Administration, oral Analgesics, opioid Clinical trial Emergency service, hospital |
| Title | Sufentanil sublingual tablet 30mcg for moderate-to-severe acute pain in the ED |
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