Assessment of methotrexate effıcacy in the treatment of ectopic pregnancy

• Published in: Namık Kemal tıp dergisi Vol. 7; no. 1; pp. 25 - 30
• Main Authors: Obut,Mehmet, Bademkıran,Muhammed Hanifi, Akgöl,Sedat, Kahveci,Bekir, Bağlı,İhsan, Oğlak,S. Cemil, Budak,Mehmet Şükrü
• Format: Journal Article
• Language: English
• Published: Galenos Yayınevi 01-04-2019; Galenos Yayincilik
• Subjects: ectopic pregnancy; medical treatment; methotrexate efficacy; success rate; Tıp; Tekirdağ; Türkiye; medikal tedavi; medical treatment; ectopic pregnancy; success rate; başarı oranı; ektopik gebelik; methotrexate efficacy; methotrexat etkinliği
• EISSN: 2587-0262

Aim: Our aim in this study was to assess efficacy of singledose
methotrexate (MTX) as medical treatment for ectopic
pregnancy (EP) by evaluating the results of patients given this
treatment.
Materials and Methods: Between September 2016 and
August 2017, the treatment outcomes of EP cases treated
with MTX at Gazi Yaşargil Training and Research Hospital of
Health Sciences University were evaluated retrospectively.
Results: In total, 126 cases treated for EP were evaluated
and 65 cases were included in the study. In cases
administered a single dose of MTX, the success rate was
80%, the failure rate was 13.8%, and the emergency surgery
rate was 6.2%. The overall success rate of the medical
treatment was 90.7% for a second dose of MTX. An
unsuccessful result was considered as less than a 15%
reduction in the beta-human chorionic gonadotropin (β-hCG)
level between 4 and 7 days after single dose MTX
administration. In all cases, the rate of emergency surgery
after treatment was 9.3%.
Conclusions: In our study, success rates in patients with EP
treated with MTX were 80% after a single dose and as high
as 90.7% when a second dose was added.