Interferon Beta-1b Level in Parkinson’s Disease: Before and After SARS-CoV-2 Vaccination

• Published in: International clinical neuroscience journal Vol. 9; no. 1; p. e23
• Main Authors: Yaprak Donmez Cakil, Ozunal, Zeynep Gunes, Karsidag, Sibel, Åžahin, Sevki
• Format: Journal Article
• Language: English
• Published: Tehran Shahid Beheshti University Functional Neurosurgery Research Centre 01-01-2022; Shahid Beheshti University of Medical Sciences
• Subjects: covid-19; cytokine; immune response; inflammation; interferon beta-1b; parkinson’s disease; vaccination
• DOI: 10.34172/icnj.2022.23
• EISSN: 2383-2096
• ISSN: 2383-1871

Background: Parkinson’s disease (PD) is a neurodegenerative disease. Immune response varies after vaccination in different patients. We aimed to evaluate interferon beta-1b (IFNβ-1b) level in patients with PD in response to inactivated SARS-CoV-2 (CoronaVac) vaccination.Methods: Eight patients with the diagnosis of idiopathic PD and followed in the outpatient clinic (stages 1-2) were enrolled. Total blood count was performed before vaccination. IFNβ-1b levels were measured by ELISA and motor examination was performed before and two hours after vaccination.Results: IFNβ-1b levels increased in three patients, whereas no change was detected in one patient and the levels decreased in four patients. Divergent responses were found related to the time of diagnosis.Conclusion:The time of PD diagnosis, as well as the age of the patients, may be responsible for the variability of the post-vaccine immune response.