Evaluation of Parathyroid Hormone Increase After Parathyroidectomy in Primary Hyperparathyroidism

• Published in: Southern Clinics of Istanbul Eurasia Vol. 31; no. 2; pp. 162 - 165
• Main Authors: Kundes, Muhammet Fikri, Kucuk, Hasan Fehmi
• Format: Journal Article
• Language: English
• Published: Istanbul Kare Publishing 01-06-2020; KARE Publishing
• Subjects: hyperparathyroidism; Hyperplasia; parathyroid hormone; parathyroidektomy; Rare diseases; Tumors; Vitamin D; Vitamin deficiency
• ISSN: 2587-0998; 2587-1404; 2587-0998
• DOI: 10.14744/scie.2019.92905

INTRODUCTION: In this study, we tried to evaluate retrospectively high levels of parathyroid hormone in patients who received parathyroidectomy due to primary hyperparathyroidism in the light of the literature search. METHODS: In this study, 121 patients who underwent surgery for primary hyperparathyroidism between September 2015 and December 2017 were retrospectively evaluated, according to gender, preoperative calcium and PTH levels, postoperative calcium and PTH levels, diagnosis, histopathological results, type of surgery, follow-up time and recurrence. We excluded patients who were unreachable. RESULTS: Mean age was 54.83±12.56 (26–82). One hundred three patients were female (85.1%). One hundred nineteen patients were diagnosed (98.4%) as adenoma, whereas two patients were diagnosed as (1.6%) hyperplasia. According to histopathological results, 103 (85.1%) adenoma, four (3.3%) carcinoma, four (3.3%) hyperplasia and 10 (8.2%) adenoma and papillary carcinoma of the thyroid were found. Preoperative mean PTH value was 301.9±470 pg/ml (79-3674 pg/ml). Preoperative mean calcium level was 10.10 mg/dl (10.10 - 13.07 mg/dl). Postoperative mean PTH value was 77.2±11.1 pg/ml (6.0- 907 pg/ml). Postperative mean calcium level was 9.38±0.7 mg/dl (6.3- 11.4 mg/dl). Mean value was 9.38±0.7 mg/dl. Mean follow-up time was 18.75±5.4 (8–28) months. Post-operative PTH elevation persisted in 17 (14.8%) patients. Nine (7.4%) of them had chronic kidney failure, three (2.4%) patients suffered from vitamin D deficiency, and five (4.1%) cases had a recurrence. DISCUSSION AND CONCLUSION: Primary hyperparathyroidism is a rare disease. In the absence of postoperative PTH decrease and normocalcemic PTH elevation should be considered as well as recurrence. Renal diseases, bone hunger and Vitamin D deficiency should be evaluated.