Dynamics and necessity of SIRT1 for maternal–zygotic transition
Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some key regulatory factors are still elusive. Sirtuin-1 (SIRT1),...
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| Published in: | Scientific reports Vol. 14; no. 1; pp. 21598 - 14 |
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| Abstract | Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some key regulatory factors are still elusive. Sirtuin-1 (SIRT1), an NAD
+
-dependent histone deacetylase, is a versatile driver of MZT via its epigenetic and nonepigenetic substrates. This study focused on the dynamics of SIRT1 in early embryos and its contribution to MZT. A conditional SIRT1-deficient knockout mouse model was used, accompanied by porcine and human embryos. Embryos across mammalian species showed the prominent localization of SIRT1 in the nucleus throughout early embryonic development. Accordingly, SIRT1 interacts with histone H4 on lysine K16 (H4K16) in both mouse and human blastocysts. While maternal SIRT1 is dispensable for MZT, at least one allele of embryonic
Sirt1
is required for early embryonic development around the time of EGA. This role of SIRT1 is surprisingly mediated via a transcription-independent mode of action. |
|---|---|
| AbstractList | Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some key regulatory factors are still elusive. Sirtuin-1 (SIRT1), an NAD
+
-dependent histone deacetylase, is a versatile driver of MZT via its epigenetic and nonepigenetic substrates. This study focused on the dynamics of SIRT1 in early embryos and its contribution to MZT. A conditional SIRT1-deficient knockout mouse model was used, accompanied by porcine and human embryos. Embryos across mammalian species showed the prominent localization of SIRT1 in the nucleus throughout early embryonic development. Accordingly, SIRT1 interacts with histone H4 on lysine K16 (H4K16) in both mouse and human blastocysts. While maternal SIRT1 is dispensable for MZT, at least one allele of embryonic
Sirt1
is required for early embryonic development around the time of EGA. This role of SIRT1 is surprisingly mediated via a transcription-independent mode of action. Abstract Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some key regulatory factors are still elusive. Sirtuin-1 (SIRT1), an NAD+-dependent histone deacetylase, is a versatile driver of MZT via its epigenetic and nonepigenetic substrates. This study focused on the dynamics of SIRT1 in early embryos and its contribution to MZT. A conditional SIRT1-deficient knockout mouse model was used, accompanied by porcine and human embryos. Embryos across mammalian species showed the prominent localization of SIRT1 in the nucleus throughout early embryonic development. Accordingly, SIRT1 interacts with histone H4 on lysine K16 (H4K16) in both mouse and human blastocysts. While maternal SIRT1 is dispensable for MZT, at least one allele of embryonic Sirt1 is required for early embryonic development around the time of EGA. This role of SIRT1 is surprisingly mediated via a transcription-independent mode of action. Dynamic changes in maternal-zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some key regulatory factors are still elusive. Sirtuin-1 (SIRT1), an NAD + -dependent histone deacetylase, is a versatile driver of MZT via its epigenetic and nonepigenetic substrates. This study focused on the dynamics of SIRT1 in early embryos and its contribution to MZT. A conditional SIRT1-deficient knockout mouse model was used, accompanied by porcine and human embryos. Embryos across mammalian species showed the prominent localization of SIRT1 in the nucleus throughout early embryonic development. Accordingly, SIRT1 interacts with histone H4 on lysine K16 (H4K16) in both mouse and human blastocysts. While maternal SIRT1 is dispensable for MZT, at least one allele of embryonic Sirt1 is required for early embryonic development around the time of EGA. This role of SIRT1 is surprisingly mediated via a transcriptionindependent mode of action. Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some key regulatory factors are still elusive. Sirtuin-1 (SIRT1), an NAD+-dependent histone deacetylase, is a versatile driver of MZT via its epigenetic and nonepigenetic substrates. This study focused on the dynamics of SIRT1 in early embryos and its contribution to MZT. A conditional SIRT1-deficient knockout mouse model was used, accompanied by porcine and human embryos. Embryos across mammalian species showed the prominent localization of SIRT1 in the nucleus throughout early embryonic development. Accordingly, SIRT1 interacts with histone H4 on lysine K16 (H4K16) in both mouse and human blastocysts. While maternal SIRT1 is dispensable for MZT, at least one allele of embryonic Sirt1 is required for early embryonic development around the time of EGA. This role of SIRT1 is surprisingly mediated via a transcription-independent mode of action. Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some key regulatory factors are still elusive. Sirtuin-1 (SIRT1), an NAD+-dependent histone deacetylase, is a versatile driver of MZT via its epigenetic and nonepigenetic substrates. This study focused on the dynamics of SIRT1 in early embryos and its contribution to MZT. A conditional SIRT1-deficient knockout mouse model was used, accompanied by porcine and human embryos. Embryos across mammalian species showed the prominent localization of SIRT1 in the nucleus throughout early embryonic development. Accordingly, SIRT1 interacts with histone H4 on lysine K16 (H4K16) in both mouse and human blastocysts. While maternal SIRT1 is dispensable for MZT, at least one allele of embryonic Sirt1 is required for early embryonic development around the time of EGA. This role of SIRT1 is surprisingly mediated via a transcription-independent mode of action.Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some key regulatory factors are still elusive. Sirtuin-1 (SIRT1), an NAD+-dependent histone deacetylase, is a versatile driver of MZT via its epigenetic and nonepigenetic substrates. This study focused on the dynamics of SIRT1 in early embryos and its contribution to MZT. A conditional SIRT1-deficient knockout mouse model was used, accompanied by porcine and human embryos. Embryos across mammalian species showed the prominent localization of SIRT1 in the nucleus throughout early embryonic development. Accordingly, SIRT1 interacts with histone H4 on lysine K16 (H4K16) in both mouse and human blastocysts. While maternal SIRT1 is dispensable for MZT, at least one allele of embryonic Sirt1 is required for early embryonic development around the time of EGA. This role of SIRT1 is surprisingly mediated via a transcription-independent mode of action. Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some key regulatory factors are still elusive. Sirtuin-1 (SIRT1), an NAD -dependent histone deacetylase, is a versatile driver of MZT via its epigenetic and nonepigenetic substrates. This study focused on the dynamics of SIRT1 in early embryos and its contribution to MZT. A conditional SIRT1-deficient knockout mouse model was used, accompanied by porcine and human embryos. Embryos across mammalian species showed the prominent localization of SIRT1 in the nucleus throughout early embryonic development. Accordingly, SIRT1 interacts with histone H4 on lysine K16 (H4K16) in both mouse and human blastocysts. While maternal SIRT1 is dispensable for MZT, at least one allele of embryonic Sirt1 is required for early embryonic development around the time of EGA. This role of SIRT1 is surprisingly mediated via a transcription-independent mode of action. |
| Author | Vaskovicova, Michaela Shavit, Miki Liska, Frantisek Hosek, Petr Kralickova, Milena Stachovicova, Sara Havrankova, Jirina Monsef, Ladan Kubovciak, Jan Iniesta-Cuerda, Maria Benc, Michal Valentova, Iveta Zalmanova, Tereza Petr, Jaroslav Nevoral, Jan Drutovic, David Strejcek, Frantisek |
| Author_xml | – sequence: 1 givenname: Jan surname: Nevoral fullname: Nevoral, Jan email: jan.nevoral@lfp.cuni.cz organization: Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Faculty of Medicine in Pilsen, Department of Histology and Embryology, Charles University – sequence: 2 givenname: David surname: Drutovic fullname: Drutovic, David organization: Institute of Animal Physiology and Genetics of the Czech Academy of Sciences – sequence: 3 givenname: Michaela surname: Vaskovicova fullname: Vaskovicova, Michaela organization: Institute of Animal Physiology and Genetics of the Czech Academy of Sciences – sequence: 4 givenname: Michal surname: Benc fullname: Benc, Michal organization: Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra – sequence: 5 givenname: Frantisek surname: Liska fullname: Liska, Frantisek organization: First Faculty of Medicine, Institute of Biology and Medical Genetics, Charles University – sequence: 6 givenname: Iveta surname: Valentova fullname: Valentova, Iveta organization: Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Pronatal Sanatorium – sequence: 7 givenname: Sara surname: Stachovicova fullname: Stachovicova, Sara organization: Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra, Université Paris-Saclay, Université de Versailles Saint-Quentin-en-Yvelines, INRAE, BREED – sequence: 8 givenname: Jan surname: Kubovciak fullname: Kubovciak, Jan organization: Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics of the Czech Academy of Sciences – sequence: 9 givenname: Jirina surname: Havrankova fullname: Havrankova, Jirina organization: Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Faculty of Medicine in Pilsen, Department of Histology and Embryology, Charles University – sequence: 10 givenname: Miki surname: Shavit fullname: Shavit, Miki organization: Faculty of Medicine in Pilsen, Biomedical Center, Charles University – sequence: 11 givenname: Ladan surname: Monsef fullname: Monsef, Ladan organization: Faculty of Medicine in Pilsen, Biomedical Center, Charles University – sequence: 12 givenname: Maria surname: Iniesta-Cuerda fullname: Iniesta-Cuerda, Maria organization: Faculty of Medicine in Pilsen, Biomedical Center, Charles University – sequence: 13 givenname: Tereza surname: Zalmanova fullname: Zalmanova, Tereza organization: Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Institute of Animal Science – sequence: 14 givenname: Petr surname: Hosek fullname: Hosek, Petr organization: Faculty of Medicine in Pilsen, Biomedical Center, Charles University – sequence: 15 givenname: Frantisek surname: Strejcek fullname: Strejcek, Frantisek organization: Faculty of Natural Sciences and Informatics, Constantine the Philosopher University in Nitra – sequence: 16 givenname: Milena surname: Kralickova fullname: Kralickova, Milena organization: Faculty of Medicine in Pilsen, Biomedical Center, Charles University, Faculty of Medicine in Pilsen, Department of Histology and Embryology, Charles University – sequence: 17 givenname: Jaroslav surname: Petr fullname: Petr, Jaroslav organization: Institute of Animal Science |
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| Keywords | Epigenetics Histone deacetylase Embryonic genome activation Embryo Oocyte, zygote Oocyte zygote Embryo Embryonic genome activation Epigenetics Histone deacetylase zygote Oocyte |
| Language | English |
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| Snippet | Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation... Dynamic changes in maternal-zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation... Abstract Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome... |
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| Title | Dynamics and necessity of SIRT1 for maternal–zygotic transition |
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