Nephrotic syndrome and Guillan-Barre syndrome : a rare association in child

• Published in: Saudi journal of kidney diseases and transplantation Vol. 21; no. 1; pp. 135 - 137
• Main Authors: Qarqash, Tahar, Mrad, Sonia Mazigh, Harz Allah, Qays, Bu Yahya, Ulfah, Azzah, Sumud al-Gharbi, Gharsallah, Lamya, Khalifi, Ibtisam, Bu Kathir, Samir
• Format: Journal Article
• Language: English
• Published: Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 2010; Medknow Publications and Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Adolescent; Adult; Biopsy; Care and treatment; Case studies; Child, Preschool; Diagnosis; Fatigue - etiology; Female; Guillain-Barre syndrome; Guillain-Barre Syndrome - complications; Guillain-Barre Syndrome - diagnosis; Guillain-Barre Syndrome - drug therapy; Guillain-Barré syndrome in children; Health aspects; Humans; Hypesthesia - etiology; Immunoglobulins, Intravenous - therapeutic use; Immunosuppressive agents; Leg; Male; Middle Aged; Muscle Weakness - etiology; Nephrotic syndrome; Nephrotic Syndrome - diagnosis; Nephrotic Syndrome - drug therapy; Nephrotic Syndrome - etiology; Nephrotic syndrome in children; Neurologic Examination; Pain - etiology; Patient outcomes; Risk factors; Steroids - therapeutic use; Treatment Outcome; الأطفال; التشخيص; المتلازمة الكلوية; المضاعفات; متلازمة غيلان باريه; Saudi Arabia
• EISSN: 2320-3838
• ISSN: 1319-2442

Only few cases of nephrotic syndrome associated with Guillain-Barre Syndrome (GBS) have been reported in the adult and pediatric literature. A 3-year-old boy was initially admitted to our hospital following five days of progressive weakness of his extremities, fatigue, right leg pain and numbness. There was no past history of renal or neurological disease. Cerebro­spinal fluid studies showed a protein level of 92 mg/dL and a white cell count of 1 per high-power field. The diagnosis of GBS was verified with a nerve conduction velocity test as well as. The GBS symptoms improved gradually on intravenous immunoglobulin. Three weeks later, he deve­loped severe proteinuria and edema; laboratory investigation showed nephrotic syndrome which responded to steroid therapy. Renal biopsy showed minimal change glomerulonephritis. He re­mained free of proteinuria during his 20 months of follow-up.