Density of mast cells and intensity of pruritus in psoriasis vulgaris: a cross sectional study

• Published in: Anais brasileiros de dermatología Vol. 93; no. 3; pp. 368 - 372
• Main Authors: Peres, Letícia Pargendler, Oliveira, Fabiana Bazanella, Cartell, André, Mazzotti, Nicolle Gollo, Cestari, Tania Ferreira
• Format: Journal Article
• Language: English
• Published: Spain Sociedade Brasileira de Dermatologia 01-06-2018
• Subjects: Adolescent; Adult; Biopsy; Cross-Sectional Studies; DERMATOLOGY; Female; Humans; Investigation; Male; Mast cells; Mast Cells - pathology; Middle Aged; Pruritus; Pruritus - pathology; Pruritus - therapy; Psoriasis; Psoriasis - pathology; Skin - pathology; Young Adult; Psoriasis; Mast cells; Pruritus
• ISSN: 0365-0596; 1806-4841; 1806-4841
• DOI: 10.1590/abd1806-4841.20186607

Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-to-control symptom. The mediators involved in psoriatic pruritus have not been fully established.
To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus.
29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed. A questionnaire was administered to obtain clinical information and the Dermatology Life Quality Index. Pruritus was assessed using a visual analog scale and skin biopsies were performed for staining with Giemsa and Immunohistochemistry with C-Kit.
Pruritus was observed in 91.3% of our patients. Median VAS was 6 (p25-75: 2-8). The immunohistochemical method revealed a mean of 11.32 mast cells/field and Giemsa staining revealed a mean of 6.72 mast cells/field. There was no correlation between the intensity of pruritus and mast cell count, neither in Immunohistochemistry (p = 0.15; rho = -0.27) nor in Giemsa (p = 0.16; rho = -0.27). Pruritus did not impact on the Dermatology Life Quality Index (p = 0.51; rho = -0.13).
The small sample size may be considered the main limitation of our study.
Although mast cells are mediators of pruritus in many cutaneous diseases, our findings support that psoriatic pruritus is a complex disorder with multifactorial, complex pathophysiology, involving pruritogenic mediators others than mast cells.