Hydrogen peroxide derived from NADPH oxidase 4- and 2 contributes to the endothelium-dependent vasodilatation of intrarenal arteries

The role of NADPH oxidase (Nox)-derived reactive oxygen species in kidney vascular function has extensively been investigated in the harmful context of oxidative stress in diabetes and obesity-associated kidney disease. Since hydrogen peroxide (H2O2) has recently been involved in the non-nitric oxid...

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Bibliographic Details
Published in:	Redox biology Vol. 19; pp. 92 - 104
Main Authors:	Muñoz, Mercedes, Martínez, María Pilar, López-Oliva, María Elvira, Rodríguez, Claudia, Corbacho, César, Carballido, Joaquín, García-Sacristán, Albino, Hernández, Medardo, Rivera, Luis, Sáenz-Medina, Javier, Prieto, Dolores
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-10-2018 Elsevier
Subjects:	Aged Animals Arteries - physiology Endothelium, Vascular - physiology Endothelium-mediated vasodilatation Female Human intrarenal arteries Humans Hydrogen peroxide Hydrogen Peroxide - metabolism Kidney - blood supply Male Middle Aged NADPH Oxidase 2 - metabolism NADPH Oxidase 4 - metabolism Nox2 Nox4 Rats, Wistar Research Paper Vasodilation NADPH NO eNOS O2 Hydrogen peroxide ACh EDH SOD H2O2 Phe COX ER PSS VSM NOS Endothelium-mediated vasodilatation Nox ROS Nox4 CYP Human intrarenal arteries EC Nox2
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