TGF-β Superfamily: an Overview of Amh Signaling into Sex Determination and Differentiation in Fish

• Published in: Brazilian Archives of Biology and Technology Vol. 66
• Main Authors: Marcos Antonio de Oliveira, Amorésio Souza Silva Filho, Fabrício Eugênio Araújo
• Format: Journal Article
• Language: English; Portuguese
• Published: Instituto de Tecnologia do Paraná (Tecpar) 2023
• Subjects: Amh; cell proliferation; fish; germ cell; sex differentiation and determination
• ISSN: 1678-4324
• DOI: 10.1590/1678-4324-2023220371

Abstract The decision whether the bipotential gonadal anlage will become a testis or ovary is a critical step during sex determination and differentiation in fish. This process involves a complex and coordinated genetic cascade, which result in the differentiation of the somatic cells into ovary or testis. In this context, important genes of TGF-β superfamily appears have a pivotal role in this biological process of fish development. In this review, we showed the breakthrough in the last decades that engage the Anti-Müllerian hormone (Amh) as an important effector in this decision. Here we exposed studies with different species of fishes around of world have paved the way for clarifying the role of Amh in the regulation of the germ cells proliferation, which may influence the spermatogenesis and, sex determination and differentiation decision on teleost fish.