Mechanism and Role of circRNA in Occurrence and Development of Hepatocellular Carcinoma

• Published in: Zhongliu fangzhi yanjiu Vol. 49; no. 5; pp. 496 - 502
• Main Authors: Zhou, Hong, Zhang, Haibo, Yan, Ruijuan, Wei, Hailiang, Yan, Shuguang, Li, Jingtao, Chang, Zhanjie
• Format: Journal Article
• Language: Chinese
• Published: Tianjin China Anti-Cancer Association 01-05-2022; Magazine House of Cancer Research on Prevention and Treatment
• Subjects: Apoptosis; biological biomarkers; biological function; Biomarkers; Cell proliferation; circrna; Diagnosis; Gene expression; hcc; Hepatocellular carcinoma; Liver cancer; miRNA; Pathogenesis; Post-transcription; Proteins; Ribonucleic acid; RNA; RNA-binding protein; Therapeutic targets; Tumor microenvironment; tumour
• ISSN: 1000-8578
• DOI: 10.3971/j.issn.1000-8578.2022.21.1072

Hepatocellular carcinoma (HCC) is the most common pathological type of primary liver cancer, with high fatality rate. The pathogenesis of HCC is complex, and the specific occurrence and development mechanism is still in the exploratory stage. CircRNA is a special endogenous noncoding RNA and mainly participates in the regulation of gene expression at the transcriptional and posttranscriptional levels. By regulating gene transcription, it acts as a molecular sponge of miRNA, participates in protein translation, and interacts with RNA binding protein (RBP). CircRNA is involved in the occurrence and development of HCC. Its abnormal expression in HCC cells is related to the pathological characteristics of HCC tissue, regulates the expression of downstream target genes, miRNA and proteins, participates in the proliferation, migration, invasion and apoptosis of HCC cells, and regulates tumor microenvironment and signal pathways, suggesting that circRNA may be a potential novel biomarker and therapeutic target for t