Synthesis, structure, and antimicrobial activity of aminated 5-chloro-6-nitrobenzofurazan with substituted anilines

A simple and efficient procedure for synthesis of nucleophilc aromatic substitution products in benzofurazan cycle on the basis of reactions of substituted anilines with 5-chloro-6-nitrobenzofurazan has been elaborated. The obtained products have a broad spectrum of antibacterial and antimycotic act...

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Bibliographic Details
Published in:	Uchenye zapiski Kazanskogo universiteta. Serii͡a︡ Estestvennye nauki Vol. 159; no. 4; pp. 564 - 574
Main Authors:	I.V. Galkina, G.L. Takhautdinova, Kh.R. Khayarov, L.M. Yusupova, O.I Gnezdilov, A.V. Ilyasov, V.I. Galkin
Format:	Journal Article
Language:	English Russian
Published:	Kazan Federal University 01-12-2017
Subjects:	5-chloro-6-nitrobenzofurazan heterocyclic compounds nucleophilc aromatic substitution structure substituted anilines synthesis
Online Access:	Get full text
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Summary:	A simple and efficient procedure for synthesis of nucleophilc aromatic substitution products in benzofurazan cycle on the basis of reactions of substituted anilines with 5-chloro-6-nitrobenzofurazan has been elaborated. The obtained products have a broad spectrum of antibacterial and antimycotic activity. The structure of compounds has been confirmed by IR-, NMR-spectroscopy and also by single-crystal X-ray analysis. Thermal stability of the products has been studied by the combined method of thermogravimetry and differential scanning calorimetry (TG-DSC).
ISSN:	2542-064X 2500-218X