Glomerular filtration rate and functional decline in an acute geriatric unit

• Published in: Iatreia (Medellín, Colombia) Vol. 31; no. 1; pp. 7 - 17
• Main Authors: Ocampo Chaparro, José Mauricio, Reyes Ortiz, Carlos Alfonso, Olmedo Hernandez, Héctor, Badiel Ocampo, Marisol, León Giraldo, Hoover
• Format: Journal Article
• Language: Spanish
• Published: Universidad de Antioquia 01-01-2018
• Subjects: Aged; Functional Decline; Glomerular Filtration Rate; Hospitalization
• ISSN: 0121-0793; 2011-7965
• DOI: 10.17533/udea.iatreia.v31n1a01

Introduction: Low estimated Glomerular filtration rate (eGFR) is associated with functional decline. Little is known on that association in hospitalized elderly. Objective: Determine if low eGFR is associated with functional decline. Methods: Prospective cohort study that included 1826 patients 60 years and older hospitalized in a Geriatric Acute Unit, admitted between January 2012 and August 2015. The outcome was functional status assessed four times by the Barthel Index (BI). Kidney function was estimated by MDRD-4 IDMS and was grouped into four categories according to eGFR (normal ≥90, mild 60-89, moderate 59-30, severe <30). Multivariate logistic regression models and GLIMMIX procedure for longitudinal analyzes were used. Results: Mean age was 82.3±7.2 years, 51 % were women. In multivariate logistic regression, a BI≤60 at admission was associated with age ≥80, female gender, high comorbidity, social deterioration, hypoalbuminemia, anemia, MMSE<19, while the presence of mild or moderate renal failure reduced this risk. In the longitudinal analysis, lower total BI at follow-up was associated with age ≥80, female gender, social deterioration, hospital stay ≥15 days, high comorbidity, hypoalbuminemia, MMSE<19. The presence of mild, moderate or severe renal impairment was associated with higher BI over time. Conclusions: A low eGFR was associated with lower risk for functional decline at admission and overtime. These findings differ from previous reports in the literature.