T 1 Mapping on Gd-EOB-DTPA-Enhanced MRI for the Prediction of Oxaliplatin-Induced Liver Injury in a Mouse Model

• Published in: Journal of magnetic resonance imaging Vol. 53; no. 3; pp. 896 - 902
• Main Authors: Yang, Li, Ding, Ying, Rao, Shengxiang, Chen, Caizhong, Zeng, Mengsu
• Format: Journal Article
• Language: English
• Published: United States 01-03-2021
• Subjects: Animals; Chemical and Drug Induced Liver Injury, Chronic; Contrast Media; Gadolinium DTPA; Liver - diagnostic imaging; Magnetic Resonance Imaging; Mice; Oxaliplatin - adverse effects; drug-induced liver injury; oxaliplatin; magnetic resonance imaging; Gd-EOB-DTPA; diagnostic imaging
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.27377

Oxaliplatin-induced liver injury (OILI) not only impairs hepatic regeneration but also increases postoperative morbidity and mortality. Therefore, noninvasive, accurate, and early diagnosis of OILI is mandatory.
To evaluate the potential of T
mapping on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI for assessing OILI in a mouse model.
Case control, animal model.
Thirty oxaliplatin-treated mice and 10 control mice were included.
Volumetric interpolated breath-hold examination sequence: 3T scanner with a phased-array animal 8-channel coil. T
mapping before and at hepatobiliary phase (HBP) after injection of Gd-EOB-DTPA were undertaken.
T
relaxation times of the liver parenchyma were measured and the reduction rate (ΔT
%) was calculated. Histological findings were used as a standard reference.
The Kruskal-Wallis test with pairwise comparisons using the Mann-Whitney U-test were applied to compare the parameters across groups. Spearman's rank correlation test and receiver operating characteristics (ROC) analyses were performed. Areas under the curves (AUCs) were compared using the DeLong method.
Histologically, mice were classified as normal (n = 10), hepatocellular degeneration without fibrosis (n = 16), and hepatocellular degeneration with fibrosis (n = 14). HBP T
relaxation time increased with the severity of OILI (rho = 0.60, P < 0.05), and ΔT
% decreased with the severity of OILI (rho = -0.78, P < 0.05). AUC was 0.92 for ΔT
% in differentiating hepatocellular degeneration without fibrosis from normal liver, but HBP T
relaxation time could not distinguish them (P = 0.09). AUCs were 0.96 and 0.95 for HBP T
relaxation time, and 0.90 and 0.84 for ΔT
% in discriminating OILI with fibrosis from normal liver and OILI without fibrosis.
HBP T
relaxation time and ΔT
% of Gd-EOB-DTPA enhanced MRI was useful for assessing OILI. ΔT
% may be more sensitive than HBP T
relaxation time in detecting early stage of liver injury.
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