Downregulation of androgen receptors by NaAsO 2 via inhibition of AKT-NF-κB and HSP90 in castration resistant prostate cancer

Androgen and androgen receptor (AR) play essential roles in the development and maintenance of prostate cancer. The recently identified AR splice variants (AR-Vs) have been considered as a plausible mechanism for the primary resistance against androgen deprivation therapy (ADT) in castration-resista...

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Bibliographic Details
Published in:	The Prostate Vol. 77; no. 10; pp. 1128 - 1136
Main Authors:	Kim, Yunlim, Park, Sang Eun, Moon, Jeong-Weon, Kim, Bong-Min, Kim, Ha-Gyeong, Jeong, In Gab, Yoo, Sangjun, Ahn, Jae Beom, You, Dalsan, Pak, Jhang Ho, Kim, Sujong, Hwang, Jung Jin, Kim, Choung-Soo
Format:	Journal Article
Language:	English
Published:	United States 01-07-2017
Subjects:	Arsenites - pharmacology Cell Line, Tumor Down-Regulation Enzyme Inhibitors - pharmacology HSP90 Heat-Shock Proteins - metabolism Humans Male NF-kappa B - metabolism Prostate - drug effects Prostate - metabolism Prostate - pathology Prostate-Specific Antigen - analysis Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - metabolism Prostatic Neoplasms, Castration-Resistant - pathology Proto-Oncogene Proteins c-akt - metabolism Receptors, Androgen - metabolism Signal Transduction - drug effects Sodium Compounds - pharmacology Treatment Outcome sodium meta-arsenite NF-κB AKT androgen receptor HDAC6 PSA
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