Abstract 3261: EOS100850, a non-brain penetrant highly selective A2Areceptor antagonist, uniquely maintains high potency within the adenosine rich tumor microenvironment

Abstract High levels of extracellular adenosine in the tumor microenvironment promote tumor immune evasion. We and others have shown that adenosine, predominantly through the A2A receptor, suppresses innate and adaptive immune cell responses leading to suppression of antitumor immunity. We demonstra...

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Bibliographic Details

Published in:	Cancer research (Chicago, Ill.) Vol. 79; no. 13_Supplement; p. 3261
Main Authors:	Houthuys, Erica, Basilico, Paola, Brouwer, Margreet, Deregnaucourt, Theo, Detheux, Michel, Driessens, Gregory, Gomes, Bruno, Leroy, Xavier, Marchante, Joao, Marillier, Reece, Swiercz, Jakub, Crosignani, Stefano
Format:	Journal Article
Language:	English
Published:	01-07-2019
Online Access:	Get full text
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