Pharmacogenetic predictors of the safety of nonsteroidal anti-inflammatory drugs

• Published in: Farmakogenetika i farmakogenomika no. 1; pp. 31 - 36
• Main Authors: Zhiryakova, A. S., Denisenko, N. P., Kryukov, A. V., Matveev, A. V., Mirzaev, K. B., Sychev, D. A.
• Format: Journal Article
• Language: English
• Published: 27-02-2023
• ISSN: 2686-8849; 2588-0527
• DOI: 10.37489/2588-0527-2022-1-31-36

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently prescribed medications; however, their use may be associated with the development of numerous adverse reactions. Purpose of work: to analyze the data of studies, in which the influence of pharmacogenetic features of patients on the safety of NSAID therapy was studied. The results of numerous studies show that the safety of NSAIDs may be associated with the CYP2C9, CYP2C8, PTGS1 and PTGS2 polymorphisms. The allele frequency of these genes varies in different ethnic groups. Thus, the development of a personalized approach based on genetic, clinical and demographic, and ethnic factors of patients will improve the safety of NSAID therapy