PI3Kδ shapes Th2 lineage restriction through coordination of IL-2 signaling, Foxo1 inactivation and epigenetic remodeling

Activated PI3K-delta syndrome (APDS) is a primary immunodeficiency caused by heterozygous activating mutations in PI3Kδ, resulting in recurrent infections as well as allergic diseases. Given that APDS patients show an inability to clear respiratory pathogens (Th1) and development of allergic disease...

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Bibliographic Details

Published in:	The Journal of immunology (1950) Vol. 210; no. 1_Supplement; pp. 76 - 76.03
Main Authors:	Golec, Dominic P, Gazzinelli-Guimaraes, Pedro, Chauss, Daniel, Hill, Tom, Nivelo, Luis, Joshi, Ilin, Pereira, Nicolas, Druey, Kirk M, Lack, Justin, Afzali, Behdad, Villarino, Alejandro, Nutman, Thomas B, Schwartzberg, Pamela L
Format:	Journal Article
Language:	English
Published:	01-05-2023
Online Access:	Get full text
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