A9611 Association between microalbuminuria and blood pressure in patients without chronic kidney disease: evidence from the aragon workers health study (AWHS)

• Published in: Journal of hypertension Vol. 36 Suppl 3; p. e168
• Main Authors: Lipe, Rafael Alvarez, Ledesma, Hilda Villafuerte, Gil, Pablo IÑIgo, Lopez, Ignacio Gimenez, Latre, Montserrat Leon, Porta, Jose Maria PeÑA, Laiglesia, Jose Esteban Ruiz, Perna, Patricia Vernet, Burillo, Alba Martinez, Caro, Amalia Perona, Latorre, Alejandro Tomas, Azara, Pilar Martin, Wennekers, Ana Berni
• Format: Journal Article
• Language: English
• Published: Copyright Wolters Kluwer Health, Inc. All rights reserved 01-10-2018
• ISSN: 0263-6352; 1473-5598
• DOI: 10.1097/01.hjh.0000548686.05389.36

OBJECTIVES:Blood pressure (BP) and albuminuria has been associated with increased cardiovascular mortality. The aim of this study was to evaluate differences in Blood pressure across albuminuria levels in patients without chronic kidney disease.
METHODS:The analysis was carried out on a sample of AWHS, whose initial design and methodology have been previously published. 2682 General Motors’ workers (Figuerelas-Spain) without chronic kidney disease were analyzed. Patients were classified according to urine albumin-to-creatinine ratio (ACR), as normoalbuminuria (< 30 mg/g) and microalbuminuria (30–300 mg/g). We excluded examinees who had ACR > 300 mg/g. Blood pressure were determined with standardized methods and conditions.
RESULTS:Systolic Blood Pressure (SBP) was 8 mmHg higher in patients with microalbuminuria than in those with normoalbuminuria (P < 0.001), and Diastolic Blood Pressure (DBP) had 5 mmHg grater than in those with normoalbuminuria (P < 0.001). Chi-square analysis revealed that microalbuminuria was correlated with the systolic blood pressure in among patients diabetes (4 mmHg, P < 0.001). In a logistic regression model adjusted for sex, age, body mass index (BMI), hypertension and diabetes revealed systolic blood pressure was statistically significantly associated with microalbuminuria (p < 0.04) (OR:1.03; 95% CI:1.01–1.05).
CONCLUSION:Albuminuria is accompanied by higher SBP in patients with and without diabetes.