USE OF INTRALESIONAL CORTICOID AND CALCITONIN NASAL SPRAY IN THE TREATMENT OF CENTRAL GIANT CELL GRANULOMA: CASE REPORT

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 130; no. 3; p. e230
• Main Authors: ÁVILA, ERYCK CANABARRA, SANTOS, ELENISA GLAUCIA FERREIRA DOS, PIMENTEL, LETíCIA MARIA CORREIA, SANTANA, SUELLEN FERNANDES, CARVALHO, CAMILLA ALVES DE, NETA, VILMA LEãO BARBOSA, MIKAMI, JOSé RICARDO
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.568

Central giant cell granuloma (CGCG) is a benign intraosseous lesion of the jaw bones that has the surgical therapy as conventional treatment. This study aimed to report the case of a patient with conservatively treated aggressive CGCG in mandible. A 29-year-old female patient presented a volumetric increase of the buccal and lingual mandible cortices, with hard consistency areas and crepitus compatible with cortical bone destruction. An incisional biopsy was performed and the histopathological examination confirmed the diagnosis. Treatment was initiated with intralesional injection of triamcinolone hexacetonide 25 mg/mL. An increase and partial calcification of the lesion was observed. The use of calcitonin salmon nasal spray (200 IU/d) was introduced for 3 months, after full calcification. The patient remains in radiographic clinical follow-up without evidence of recurrence or growth. The combination of corticosteroids and calcitonin was shown to be effective in treating aggressive CGCG as a conservative alternative to surgical resection.