AGGRESSIVE DIFFUSE LARGE B-CELL LYMPHOMA IN ANTERIOR MAXILLARY REGION: CASE REPORT

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 129; no. 1; p. e87
• Main Authors: FALCÃO, GLEICY GABRIELA V.S.C., ALVES, CAROLINA GUIMARÃES BONFIM, DE JESUS MOUREIRA, PEDRO ANTONIO, DA COSTA VIEIRA, VINICIUS, RIBEIRO, PATRICIA MIRANDA LEITE, KUSTERER, LILIANE ELZE FALCÃO LINS, SARMENTO, VIVIANE ALMEIDA
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-01-2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2019.06.358

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma and is rarely seen in the maxillofacial region. A case of DLBCL in a 50-year-old man who is immunocompetent (no reagent HIV-1 and -2, and human T-cell lymphotropic virus tests) is reported. The patient complained of a painful and aberrant mass in the anterior maxillary region with fast growing in 2 months. A facial computed tomography (CT) shows a large mass with soft tissue density, measuring approximately 7.4 × 6.6 cm, which invaded and destroyed the maxillary bone. The incisional biopsy showed an undifferentiated malignant neoplasm compatible with lymphoma. Immunohistochemical analysis proved the lesion to be a DLBCL, strongly positive for CD20 and CD79 a, weakly positive for VS38 c+ and Bc16 e MUM1, and negative for CD3, cyclin A D1, CD7, C43, CD10, B CD30, and CS1-4. The proliferation index, as indicated by Ki-67 immunohistochemistry, was over 80%. The patient was referred for oncological treatment.