FACTORS ASSOCIATED WITH THE SURVIVAL OF YOUNG AND ELDERLY INDIVIDUALS DIAGNOSED WITH ORAL SQUAMOUS CELL CARCINOMA

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 130; no. 3; p. e274
• Main Authors: PIRES, ALESSANDRA LAíS PINHO VALENTE, AMORIM, MARíLIA DE MATOS, OLIVEIRA, ANA CARLA BARBOSA DE, MOURA, JAMILLE RIOS, LISBOA, LIDIANE DE JESUS, SANTOS, JEAN NUNES DOS, FREITAS, VALéRIA SOUZA
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.747

Objective: To compare the profile and overall survival of young and elderly individuals diagnosed with oral squamous cell carcinoma (SCC). Study Design: This is an observational study, developed from a retrospective cohort of cases of SCC registered in a unit of high complexity in oncology, from 2010-2016. Survival rate curves have been estimated using the Kaplan-Meier method. The predictor variables were tested using the log-rank test and those with statistical significance (P< .05) were maintained for the Cox regression model. Results: There were 282 cases, with only 12.4% diagnosed in young people. In both groups, the disease affected male individuals, smokers, and chronic alcoholics. The lesions in the tongue were diagnosed at an advanced stage, resulting in 35.7% of deaths. The median survival time was 30 months in the elderly and 31 months in the young. In the multivariate analysis, only staging (HR= 9.8; p=0.002) and treatment (HR=0.36; p=0.000) were predictors of overall survival reduction in Young and elderly. Conclusion: The profile of the youngsters was similar to that of the studied elderly. The staging of the tumor and the type of treatment performed showed statistical significance, suggesting that these variables as prognostic factors for the disease.