ACTINIC CHEILITIS: CLINICAL ANALYSIS INDEX

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 129; no. 1; p. e163
• Main Authors: MEDEIROS, CRISTIANNE KALINNE SANTOS, DE OLIVEIRA, ANNA ELLYSE GRANT, DE MEDEIROS, ANA MYRIAM COSTA, DA SILVEIRA, ÉRICKA JANINE DANTAS, DE SOUZA LOPES, MARIA LUIZA DINIZ, DE LIMA, KENIO COSTA, DE OLIVEIRA, PATRÍCIA TEIXEIRA
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-01-2020
• DOI: 10.1016/j.oooo.2019.06.696
• EISSN: 2212-4411
• ISSN: 2212-4403

To develop a Clinical Index for Actinic Cheilitis (CIAC) with the intention of assisting in the identification of clinical characteristics that indicate a greater severity of this condition.
CIAC was developed through the opinion of experts, being applied in 20 patients with QA and indicated for biopsy. The scores obtained after application of the index were associated with the histopathologic grading for oral epithelial dysplasia from the World Health Organization (WHO) and the Binary System using Fisher exact test (P < .05). The reliability of the index was tested based on the percentage of sensitivity, specificity, positive predictive value (PPV), negative predictive value, accuracy, and receiver operating characteristic (ROC) curve.
There was no statistically significant association between clinical characteristics and degree of dysplasia. The cut-off point with value 11 exhibited better performance for ROC curve and higher percentage for specificity, PPV, and accuracy in both histopathologic grading analyzed.
The cut-off point 11 can be used to indicate higher degree of severity of the AC, suggesting that out of this score patients are indicated for biopsy. The size of the sample and the need to verify the reproducibility of the index make it necessary to carry out further researches.