CORRELATION BETWEEN TNFα POLYMORPHISM AND PROGRESSION OF PERIODONTITIS IN PATIENTS ON HEMODIALYSIS

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 130; no. 3; p. e273
• Main Authors: PEREZ, MARIANA DE MORAES CORRêA, RIBEIRO, MARIA IZABEL, TRINDADE, LEONARDO ANTUNES, MAIOR, LAURA DE FáTIMA SOUTO, GUEIROS, LUIZ ALCINO MONTEIRO, LEÃO, JAIR CARNEIRO, CARVALHO, ALESSANDRA DE ALBUQUERQUE TAVARES
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.744

Objective: To characterize the influence of the tumor necrosis factor-alpha (TNFα) 308 G/A polymorfism on periodontal disease in patient on renal hemodialysis. Study design: Eighty-four patients were divided into 2 groups, of which 43 were on hemodialysis and 41 were not on hemodialysis (control group). The patient history was obtained from anamnesis, and periodontal examination and blood collection of 5 mL were performed. DNA was extracted from whole blood and genotyped to detect single nucleotide polymorphisms (SNPs) using the TaqMan method in real time. Results: The absolute and relative frequency of TNF genes (genotypes and alleles) for the variables systemic disease and periodontitis degree/localization did not present statistically significant differences in any of the groups (P> .05). The percentage of faces with plaque presented differences with statistical significance only in the control group in the genotype (P = .030) and presence of the allele A (P = .010). Conclusion: The findings indicate that were no significant differences in relation to the alleles and genotypes analyzed in both groups.