EXPRESSION OF TERATOCARCINOMA-DERIVED GROWTH FACTOR-1 (CRIPTO-1) IN EPITHELIAL ODONTOGENIC LESIONS

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 130; no. 3; p. e245
• Main Authors: SEVERO, Mara Luana Batista, SILVA, Leorik Pereira da, SILVA, Luiz Arthur Barbosa da, SOUZA, Lélia Batista de, GALVÃO, Hébel Cavalcanti, SILVEIRA, Éricka Janine Dantas da, MIGUEL, Márcia Cristina da Costa
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.634

Objective: To evaluate the immunohistochemical expression of CRIPTO-1 in odontogenic cysts and tumors. Study Design: Thirty ameloblastomas, 30 keratocysts, 30 dentigerous cysts, and 2 ameloblastic carcinomas were evaluated using the biotin-free immunoperoxidase technique. The immunohistochemical expression was analyzed from the immunoreactive score (IRS). Kruskal Wallis and Mann-Whitney U tests were performed for statistical analysis (P ≤ .05). Results: Ages ranged from 9 to 75 years, with female gender being the most prevalent (n = 49; 53.3%). The mandible was the most affected anatomic site (n = 69; 75.0%). Immunoexpression of CRIPTO-1 was observed in all cases of ameloblastoma, keratocyst, and ameloblastic carcinoma; however, 9 cases (30%) of dentigerous cysts were negative. Expression scores were higher in cases of ameloblastomas, keratocysts, and ameloblastic carcinomas (median, 8-11) compared with cases of dentigerous cysts (median, 2) being statistically significant (P < .001). Conclusion: CRIPTO-1 is critically important in the progression of some tumor types because it is related to the transforming growth-Factor-beta (TGFβ) and epidermal growth factor receptor (EGFR) pathways. The high expression of CRIPTO-1 in more aggressive odontogenic lesions suggests that this molecule may be involved in the activation of important pathways related to the pathogenesis of these lesions.