POLYMORPHOUS ADENOCARCINOMA IN THE PALATE PRESENTING TYROSINE-RICH CRYSTALLOIDS

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 130; no. 3; p. e131
• Main Authors: SILVEIRA, HEITOR ALBERGONI DA, DOMINGUETE, MATHEU HENRIQUE LOPES, GRACIANO, KAMILA PRADO PEREIRA, FERNANDES, DARCY, ALMEIDA, LUCIANA YAMAMOTO, RIBEIRO-SILVA, ALFREDO, LEÓN, JORGE ESQUICHE
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.103

Polymorphous adenocarcinoma (PAC) represents the second most common malignancy of the minor salivary glands. Uncommonly, intratumoral crystalloid deposits may be visualized in PAC. The main types include tyrosine-rich, collagenous, and amylase crystalloids. Here, we reported a case of a 49-year-old black female who was referred complaining of swelling on the hard palate. Clinically, a nodular lesion was observed measuring 4 cm in greater diameter, well-delimited, asymptomatic, and covered by normal-appearing oral mucosa, with time of evolution of 2 years. After incisional biopsy, microscopic examination revealed low-grade PAC containing foci of tyrosine-rich crystalloid deposits. Immunohistochemical analysis revealed positivity for CK AE1/3, CK7, vimentin, α-smooth muscle actin, and Bcl-2, S100, and focally for p53, GFAP, and CD10. The patient was referred to a reference service for treatment, and there has been no evidence of recurrence after 8 months’ of follow-up.