STUDY OF THE CELLULAR CANNIBALISM OF CENTRAL AND PERIPHERAL LESIONS OF THE JAWS

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 130; no. 3; p. e270
• Main Authors: SANTOS, LUIZ MIGUEL DA ROCHA, SEVERO, MARA LUANA BATISTA, BARROS, CAIO CéSAR DA SILVA, FRANÇA, GLóRIA MARIA DE, MIGUEL, MáRCIA CRISTINA DA COSTA, SILVEIRA, ÉRICKA JANINE DANTAS DA
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.732

Objective: This study analyzed the role of cellular cannibalism in the pathogenesis of peripheral giant cell lesions (PCGLs) and central giant cell lesions (CGCLs). Study Design: This is a retrospective and quantitative study of 42 cases of PCGLs and 43 cases of CGCLs (24 aggressive and 19 nonaggressive). It was analyzed by hematoxylin-eosin staining of the number of cannibalistic cells in the giant cells (GC) of this lesions. Results: Cannibalistic GCs were seen in 17 cases of CGCLs (39.5%) and in 34 cases of PCGLs (80.9%). The quantity of cannibalistic GCs ranged from 1.0 to 142.0 with a total mean ± standard deviation (SD) of 12.15 ± 24.87. The cannibalistic GCs was higher in PCGLs (19.5 ± 28.2) than CGCLs (5.04 ± 18.8) with statistical significance (P< .001). In aggressive CGCLs, cannibalistic GC frequency was significantly higher (n = 24; 55%) than the nonaggressive type (n = 19; 45%) with statistical significance (P = .001). In CGCLs, cannibalistic GC frequency was significantly higher in fast growing lesions (P = .037), lesions with irregular borders (P = .045), and symptomatic (P = .020) in the CGCLs. Conclusion: Our results suggest that frequency of cannibalistic cells in CGCLs could help in predicting the biological behavior in these lesions.