INTRA-ORAL ADULT-TYPE JUVENILE XANTHOGRANULOMA, NODULAR VARIANT: A REPORT OF A CASE WITH IMMUNOHISTOCHEMICAL STUDY

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 130; no. 3; p. e135
• Main Authors: COLTURATO, CARLA BENTO NELEM, CARIRI-NETO, ELDON GUTTENBERG, SILVEIRA, HEITOR ALBERGONI DA, ALMEIDA, LUCIANA YAMAMOTO, RIBEIRO-SILVA, ALFREDO, VANZOLIN, BÁRBARA FRANCÉ, LEÓN, JORGE ESQUICHE
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.122

Intra-oral juvenile xanthogranuloma (JXG) is a non‐Langerhans cell histiocytosis often affecting infants and children. Approximately 10% of these cases represent “adult xanthogranulomas.” To date, 33 intra-oral JXG cases have been reported. Due to its benign and self‐limiting nature, this disorder can be considered a reactive rather than a neoplastic process, although its pathogenesis remains unknown. There are 2 clinical JXG variants: papular and nodular. A 46-year-old female patient was referred presenting with a yellowish oval nodule, with circumscribed margin, measuring 1 cm in diameter, smooth-surfaced, asymptomatic, and located on the right buccal mucosa. Microscopically, it was composed mainly by numerous mononuclear macrophages containing fine cytoplasmic vacuoles in the cytoplasm, with a lipidized or xanthomatous appearance. Immunohistochemistry showed positivity for CD11c, CD68, CD163, HLA-DR, and FXIIIa. The Ki-67 labeling index was 3%. The predominant xanthomatous appearance in intra-oral JXG is uncommon, but it should be considered to exclude other xanthomatous lesions.