LANGERHANS CELL SARCOMA INVOLVING THE ORAL CAVITY

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 134; no. 3; p. e150
• Main Authors: De Lima Morais, Thayná Melo, Miranda, Águida Maria Menezes Aguiar, De Noronha Santos Netto, Juliana, López, Bruna Sena, Costa, Luiz Roberto Fernandes, De Almeida, Oslei Paes, Pires, Fábio Ramoa
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2022
• DOI: 10.1016/j.oooo.2022.01.371
• EISSN: 2212-4411
• ISSN: 2212-4403

Langerhans cell sarcoma (LCS) is a high-grade neoplasm with overtly malignant cytological features and a Langerhans cell phenotype. Only one previous case has been reported in the oral cavity. A 79-year-old male patient presented for evaluation of multiple lesions affecting the lower lip, hard palate, upper alveolar mucosa, and skin. Biopsy of the lesions affecting the lower lip and palate showed a proliferation of histiocytic cells presenting atypia, pleomorphism, and atypical mitoses. Diagnosis of LCS was supported by immunoreactivity of the neoplastic cells for S-100, CD1a, CD207, and CD83. The patient died from widespread disease 3 months after diagnosis. Due to its rarity, LCS poses a diagnostic problem in the oral cavity and should be considered in the differential diagnosis of histiocytic proliferations.