Bone damage during primary hyperparathyroidism

• Published in: Annales d'endocrinologie Vol. 85; no. 5; p. 472
• Main Authors: Ben Ammar, C., Tbini, M., Riahi, I., Ben Nacef, I., Ben Salah, M.
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01-10-2024
• DOI: 10.1016/j.ando.2024.08.321
• ISSN: 0003-4266

The objective of our study is to evaluate the prevalence and factors associated with bone damage during primary hyperparathyroidism (PHPT).
Retrospective study carried out in the otorhinolaryngology department involving 156 patients with PHTP between 2010 and 2020.
The average age was 45.7 years. A clear female predominance was noted (111 women, fifty of whom are postmenopausal). The circumstances of discovery were dominated by bone symptoms in 80% of cases (bone pain in all cases, pathological symptoms in 10%). The average serum calcium was 115mg/mL. Average PTH of 629ng/mL. Hypovitaminosis was noted in 50 cases. The prevalence of osteopenia was 34.5% and that of osteoporosis was 68.4% of cases. The mean T-score was −2.2±1.8 SD at the femoral site and −1.85±1.5 DS at the vertebral site. The results of multivariate analysis revealed a statistically significant correlation between T-score and age, PTH level and vitamin D status (P<0.001). No significant link was found between the T-score and sex, serum calcium level and smoking (P>0.05).
Although hyperparathyroidism is primarily known for its impact on mineral homeostasis, it also has a significant impact on bone health. Our results highlight the high prevalence of bone fragility in patients with PHTP, highlighting the significant impact of hyperparathyroidism on bone health.