B-CELL LYMPHOBLASTIC LYMPHOMA AFFECTING THE MAXILLA: A CASE REPORT AND IMMUNOHISTOCHEMICAL ANALYSIS

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 130; no. 3; pp. e113 - e114
• Main Authors: SILVEIRA, HEITOR ALBERGONI DA, SOUSA, LUCAS MOURA, BARBEIRO, CAMILA DE OLIVEIRA, ALMEIDA, LUCIANA YAMAMOTO, SVERZUT, CASSIO EDVARD, TRIVELLATO, ALEXANDRE ELIAS, LEÓN, JORGE ESQUICHE
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.020

Lymphoblastic lymphoma (LBL) is a malignant neoplasia that originates from B or T lymphocyte precursors and comprises approximately 2% of all non-Hodgkin lymphoma cases. Maxillofacial region involvement by LBL is rare. We report a case of a 14-year-old female patient who was referred after complaining of pain, bleeding, and swelling on the right side of the maxilla. Computed tomography showed a solid mass over the entire region, reaching the maxillary sinus and nasal cavity. An incisional biopsy was performed, which revealed large areas of lymphoid proliferation containing small- to medium-sized immature-appearing cells with scarce cytoplasm. Immunohistochemical analysis was positive for PAX5, CD79 a, TdT, CD10, Bcl-2, Bcl-6, and MUM-1; Ki-67 labeling index >96%. EBER 1/2 was negative. The patient was referred to hematologic and oncology service, but unfortunately died after starting chemotherapy. In conclusion, LBL, although rare, should be included in the differential diagnosis of maxillary osteolytic, expansive lesions, especially in pediatric patients.