Asymmetric reduction of 7,8‐difluoro‐3‐methyl‐2 H ‐1,4‐benzoxazine. Synthesis of a key intermediate of ( S )‐(‐)‐ofloxacin (DR‐3355)

Asymmetric reduction of 7,8‐difluoro‐3‐methyl‐2 H ‐1,4‐benzoxazine. Synthesis of a key intermediate of ( S )‐(‐)‐ofloxacin (DR‐3355)

An efficient, highly enantioselective synthesis of ( S )‐(‐)‐7,8‐difluoro‐2,3‐dihydro‐3‐methyl‐4 H ‐1,4‐benzoxazine, a key intermediate of ( S )‐(‐)‐ofloxacin, using various chiral sodium triacyloxyborohydrides as reducing agents is reported.

Saved in:
Bibliographic Details
Published in:Journal of heterocyclic chemistry Vol. 28; no. 2; pp. 329 - 331
Main Authors: Atarashi, Shohgo, Tsurumi, Hideaki, Fujiwara, Toshihiro, Hayakawa, Isao
Format: Journal Article
Language:English
Published: 01-02-1991
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient, highly enantioselective synthesis of ( S )‐(‐)‐7,8‐difluoro‐2,3‐dihydro‐3‐methyl‐4 H ‐1,4‐benzoxazine, a key intermediate of ( S )‐(‐)‐ofloxacin, using various chiral sodium triacyloxyborohydrides as reducing agents is reported.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570280222