PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae

Perfluorooctane sulfonate (PFOS) is a widely spread environmental contaminant. It accumulates in the brain and has potential neurotoxic effects. The exposure to PFOS has been associated with higher impulsivity and increased ADHD prevalence. We investigated the effects of developmental exposure to PF...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 4; p. e94227
Main Authors:	Spulber, Stefan, Kilian, Pascal, Wan Ibrahim, Wan Norhamidah, Onishchenko, Natalia, Ulhaq, Mazhar, Norrgren, Leif, Negri, Sara, Di Tuccio, Marcello, Ceccatelli, Sandra
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01-04-2014 Public Library of Science (PLoS)
Subjects:	Akathisia, Drug-Induced Alkanesulfonic Acids - metabolism Alkanesulfonic Acids - toxicity Analysis Animals Attention deficit hyperactivity disorder Biology and Life Sciences Brain Contaminants Danio rerio Dextroamphetamine Dextroamphetamine - pharmacology Dopamine receptors Embryos Environmental Exposure Environmental Sciences Exposure Fish and Aquacultural Science Fishes Fisk- och akvakulturforskning Fluorocarbons - metabolism Fluorocarbons - toxicity Genetic aspects Gestation Habituation Habituation (learning) Health aspects Hyperactivity Impulsive behavior Larva - drug effects Larvae Medicin och hälsovetenskap Mice Miljövetenskap Neurosciences Neurotoxicity Neurovetenskaper Perfluorooctane sulfonic acid Physiological aspects Rodents Sensorimotor integration Startle response Surface active agents Swimming Zebra fish Zebrafish Zebrafish - physiology Sweden Malaysia
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